Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Center for Pituitary Tumor Surgery, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Cell Immunol. 2020 Jun;352:104085. doi: 10.1016/j.cellimm.2020.104085. Epub 2020 Mar 6.
Asthma is a disease of the respiratory system that is commonly considered a T-helper 2 (Th2) cell-associated inflammatory disease. Group 2 innate lymphoid cells (ILC2s) promote the inflammatory responses in asthma by secreting type 2 cytokines. Interleukin (IL)-9 also serves as a promoting factor in asthma and it is well known that ILC2s have an autocrine effect of IL-9 to sustain their survival and proliferation. However, the specific role of ILC2-derived IL-9 in asthma remains unclear. HMGB1 (High-Mobility Group Box-1) is a nuclear protein, and Previous studies have shown that HMGB1 can regulate the differentiation of T-helper cells and participate in the development of asthma. But whether HMGB1 can regulate the innate lymphocytes in the pathological process of asthma is unknown. In this study we have shown increased presence of HMGB1 protein in the lung of mice with asthma, which was associated with increased secretion of IL-9 by ILC2s. This led to the activation of dendritic cells (DCs) that can accelerate the differentiation of Th2 cells and worsen the severity of asthma. Taken together, our study provides a complementary understanding of the asthma development and highlights a novel inflammatory pathway in the pathogenesis of asthma.
哮喘是一种呼吸系统疾病，通常被认为是与辅助性 T 细胞 2（Th2）细胞相关的炎症性疾病。2 型固有淋巴细胞（ILC2）通过分泌 2 型细胞因子促进哮喘中的炎症反应。白细胞介素（IL）-9 也是哮喘的促进因子，众所周知，ILC2 具有 IL-9 的自分泌作用，以维持其存活和增殖。然而，ILC2 衍生的 IL-9 在哮喘中的具体作用仍不清楚。高迁移率族蛋白 B1（HMGB1）是一种核蛋白，先前的研究表明 HMGB1 可以调节辅助性 T 细胞的分化，并参与哮喘的发生。但是，HMGB1 是否可以调节哮喘病理过程中的先天淋巴细胞尚不清楚。在这项研究中，我们已经表明哮喘小鼠肺组织中 HMGB1 蛋白的含量增加，这与 ILC2 分泌的 IL-9 增加有关。这导致树突状细胞（DC）的激活，从而加速 Th2 细胞的分化，并加重哮喘的严重程度。总之，我们的研究提供了对哮喘发展的补充理解，并强调了哮喘发病机制中的一条新的炎症途径。
