School of Medicine, Department of Pathology, Stanford University, CA, USA.
Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Semin Cancer Biol. 2020 Nov;66:171-181. doi: 10.1016/j.semcancer.2020.03.010. Epub 2020 Mar 19.
Autophagy is being explored as a potential therapeutic target for enhancing the cytotoxic effects of chemotherapeutic regimens in various malignancies. Autophagy plays a very important role in cancer pathogenesis. Here, we discuss the updates on the modulation of autophagy via dynamic interactions with different organelles and the exploitation of selective autophagy for exploring therapeutic strategies. We further discuss the role of autophagy inhibitors in cancer preclinical and clinical trials, novel autophagy inhibitors, and challenges likely to be faced by clinicians while inducting autophagy modulators in clinical practice.
自噬作用正在被探索作为一种潜在的治疗靶点，以增强各种恶性肿瘤中化疗方案的细胞毒性作用。自噬作用在癌症发病机制中起着非常重要的作用。在这里，我们讨论了通过与不同细胞器的动态相互作用来调节自噬作用，以及利用选择性自噬作用来探索治疗策略的最新进展。我们进一步讨论了自噬抑制剂在癌症临床前和临床试验中的作用、新型自噬抑制剂，以及临床医生在临床实践中诱导自噬调节剂时可能面临的挑战。
