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Emerging strategies to effectively target autophagy in cancer.有效靶向癌症自噬的新兴策略。
Oncogene. 2016 Jan 7;35(1):1-11. doi: 10.1038/onc.2015.99. Epub 2015 Apr 20.
2
Autophagy therapeutics: preclinical basis and initial clinical studies.自噬疗法：临床前基础与初步临床研究。
Cancer Chemother Pharmacol. 2018 Dec;82(6):923-934. doi: 10.1007/s00280-018-3688-3. Epub 2018 Sep 17.
3
Autophagy modulation: a target for cancer treatment development.自噬调节：癌症治疗发展的一个靶点。
Cancer Chemother Pharmacol. 2015 Mar;75(3):439-47. doi: 10.1007/s00280-014-2637-z. Epub 2014 Nov 25.
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Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors.癌症中的自噬靶向治疗：临床试验与新型抑制剂的最新进展
Int J Mol Sci. 2017 Jun 16;18(6):1279. doi: 10.3390/ijms18061279.
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Autophagy modulation: a prudent approach in cancer treatment?自噬调控：癌症治疗的谨慎之道？
Cancer Chemother Pharmacol. 2018 Dec;82(6):913-922. doi: 10.1007/s00280-018-3669-6. Epub 2018 Sep 4.
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The roles of therapy-induced autophagy and necrosis in cancer treatment.治疗诱导的自噬和坏死在癌症治疗中的作用。
Clin Cancer Res. 2007 Dec 15;13(24):7271-9. doi: 10.1158/1078-0432.CCR-07-1595.
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Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy.癌症中的自噬信号传导及其作为改善抗癌治疗新靶点的潜力。
Drug Resist Updat. 2007 Aug-Oct;10(4-5):135-43. doi: 10.1016/j.drup.2007.05.001. Epub 2007 Jul 12.
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Complex regulation of autophagy in cancer - integrated approaches to discover the networks that hold a double-edged sword.癌症中自噬的复杂调控——发现双刃剑网络的综合方法。
Semin Cancer Biol. 2013 Aug;23(4):252-61. doi: 10.1016/j.semcancer.2013.06.009. Epub 2013 Jun 28.
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Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagy.癌症中自噬的治疗靶向。第二部分：治疗诱导自噬的药理学调节。
Semin Cancer Biol. 2015 Apr;31:99-105. doi: 10.1016/j.semcancer.2014.06.001. Epub 2014 Jun 14.
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Autophagy in cancer: Recent advances and future directions.自噬在癌症中的作用：最新进展与未来方向。
Semin Cancer Biol. 2020 Nov;66:171-181. doi: 10.1016/j.semcancer.2020.03.010. Epub 2020 Mar 19.
引用本文的文献
1
Targeting Cancer Cell Fate: Apoptosis, Autophagy, and Gold Nanoparticles in Treatment Strategies.靶向癌细胞命运：治疗策略中的细胞凋亡、自噬与金纳米颗粒
Curr Issues Mol Biol. 2025 Jun 14;47(6):460. doi: 10.3390/cimb47060460.
2
The role of autophagy in cancer: from molecular mechanism to therapeutic window.自噬在癌症中的作用：从分子机制到治疗窗口
Front Immunol. 2025 Apr 3;16:1528230. doi: 10.3389/fimmu.2025.1528230. eCollection 2025.
3
Autophagy in cancer resistance: New combinatorial strategy for cancer therapy.癌症抗性中的自噬：癌症治疗的新联合策略。
Leukemia. 2024 Oct;38(10):2289-2290. doi: 10.1038/s41375-024-02342-3. Epub 2024 Aug 15.
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Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview.组蛋白去乙酰化酶抑制剂与放射治疗的作用机制序列：概述
Pharmaceuticals (Basel). 2024 May 8;17(5):602. doi: 10.3390/ph17050602.
5
Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach.四氢咯啉衍生物 NNC-55-0396 靶向脑胶质母细胞瘤微环境中的缺氧细胞：一种器官芯片方法。
Cell Death Dis. 2024 Feb 10;15(2):127. doi: 10.1038/s41419-024-06492-1.
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Role of TBK1 Inhibition in Targeted Therapy of Cancer.TBK1抑制在癌症靶向治疗中的作用
Mini Rev Med Chem. 2024;24(10):1031-1045. doi: 10.2174/0113895575271977231115062803.
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells.羟氯喹在人TK6细胞中的弱遗传毒性评估。
Toxicol Lett. 2024 Mar;393:84-95. doi: 10.1016/j.toxlet.2024.01.012. Epub 2024 Feb 2.
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Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis.线粒体氧化磷酸化和糖酵解引起的代谢可塑性在肿瘤发生的起始和进展中的调节作用。
Int J Mol Sci. 2023 Apr 11;24(8):7076. doi: 10.3390/ijms24087076.
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Modulation of redox homeostasis: A strategy to overcome cancer drug resistance.氧化还原稳态的调节：一种克服癌症耐药性的策略。
Front Pharmacol. 2023 Mar 22;14:1156538. doi: 10.3389/fphar.2023.1156538. eCollection 2023.
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The Role of Autophagy in Breast Cancer Metastasis.自噬在乳腺癌转移中的作用
Biomedicines. 2023 Feb 18;11(2):618. doi: 10.3390/biomedicines11020618.
本文引用的文献
1
Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.细胞自噬性死亡：新的分子机制及其在癌症治疗中的意义。
Oncogene. 2015 Oct 1;34(40):5105-13. doi: 10.1038/onc.2014.458. Epub 2015 Jan 26.
2
Identification of secreted proteins that reflect autophagy dynamics within tumor cells.鉴定反映肿瘤细胞内自噬动态的分泌蛋白。
Autophagy. 2015;11(1):60-74. doi: 10.4161/15548627.2014.984273.
3
Metabolic control of autophagy.自噬的代谢调控
Cell. 2014 Dec 4;159(6):1263-76. doi: 10.1016/j.cell.2014.11.006.
4
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.自噬非依赖性双向作用的 Beclin 1 通过降解 Mcl-1 抑制肿瘤发生。
Nat Commun. 2014 Dec 4;5:5637. doi: 10.1038/ncomms6637.
5
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.AMBRA1 通过促进 c-Myc 去磷酸化和降解，将自噬与细胞增殖及肿瘤发生联系起来。
Nat Cell Biol. 2015 Jan;17(1):20-30. doi: 10.1038/ncb3072. Epub 2014 Dec 1.
6
Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.微管蛋白高度乙酰化通过促进自噬在心脏蛋白质毒性中具有适应性。
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5178-86. doi: 10.1073/pnas.1415589111. Epub 2014 Nov 17.
7
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.Foxk 蛋白抑制饥饿诱导的萎缩和自噬程序的启动。
Nat Cell Biol. 2014 Dec;16(12):1202-14. doi: 10.1038/ncb3062. Epub 2014 Nov 17.
8
Nivolumab in previously untreated melanoma without BRAF mutation.纳武利尤单抗治疗未经 BRAF 突变检测的初治黑色素瘤。
N Engl J Med. 2015 Jan 22;372(4):320-30. doi: 10.1056/NEJMoa1412082. Epub 2014 Nov 16.
9
Regulation of autophagy by protein post-translational modification.蛋白质翻译后修饰对自噬的调控。
Lab Invest. 2015 Jan;95(1):14-25. doi: 10.1038/labinvest.2014.131. Epub 2014 Nov 3.
10
Autophagy is essential for effector CD8(+) T cell survival and memory formation.自噬对于效应性 CD8(+) T 细胞的存活和记忆形成至关重要。
Nat Immunol. 2014 Dec;15(12):1152-61. doi: 10.1038/ni.3025. Epub 2014 Nov 2.
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