Rebecca V W, Amaravadi R K
The Department of Medicine and Abramson Cancer Center; University of Pennsylvania School of Medicine, Philadelphia, PA USA.
Oncogene. 2016 Jan 7;35(1):1-11. doi: 10.1038/onc.2015.99. Epub 2015 Apr 20.
Autophagy serves a dichotomous role in cancer and recent advances have helped delineate the appropriate settings where inhibiting or promoting autophagy may confer therapeutic efficacy in patients. Our evolving understanding of the molecular machinery responsible for the tightly controlled regulation of this homeostatic mechanism has begun to bear fruit in the way of autophagy-oriented clinical trials and promising lead compounds to modulate autophagy for therapeutic benefit. In this manuscript we review the recent preclinical and clinical therapeutic strategies that involve autophagy modulation in cancer.
自噬在癌症中发挥着双重作用，最近的进展有助于明确在哪些适当情况下抑制或促进自噬可能对患者产生治疗效果。我们对负责这种稳态机制严格调控的分子机制的不断深入理解，已开始在以自噬为导向的临床试验以及有望用于调节自噬以获得治疗益处的先导化合物方面取得成果。在本手稿中，我们综述了近期涉及癌症自噬调节的临床前和临床治疗策略。
