特拉特果实水醇提取物对高脂喂养大鼠高脂血症的有益作用。
Beneficial Effects of Hydroalcoholic Extract from Tratt Fruit on Hyperlipidemia in High-Fat-Fed Rats.
作者信息
Wu Pin-Hsin, Han Samuel Chieng-Haw, Wu Meng-Hsiu
机构信息
Guang Zhou University of Chinese Medicine.
Department of Surgery, Nan Men General Hospital, Hsinichu City.
出版信息
Acta Cardiol Sin. 2020 Mar;36(2):148-159. doi: 10.6515/ACS.202003_36(2).20190709A.
Abstract
BACKGROUND
Rosa roxburghii Tratt fruit is extensively used as a medicinal and edible resource in China due to its unique bioactivities. In this research, we aimed to characterize its phenolic acid composition and investigate the potential hypolipidemic effect of this plant in a rat model of hyperlipidemia.
METHODS
We evaluated the effects of hydroalcoholic extract of Rosa roxburghii Tratt fruit (HRT) on serum lipids, body weight, activities of lipoprotein metabolism and antioxidant enzymes, and gene expression of lipid metabolism in hyperlipidemic rats.
RESULTS
HRT significantly reduced body weight gain and decreased serum and liver lipid levels in the hyperlipidemic rats. In addition, HRT treatment improved the activities of antioxidant enzymes, lipoprotein lipase, and hepatic lipase, downregulated the mRNA and protein expressions of sterol regulatory element-binding protein 1c and acetyl CoA carboxylase, and upregulated the mRNA and protein expressions of peroxisome proliferator-activated receptor α and low-density lipoprotein receptor in hepatic tissue.
CONCLUSIONS
The results showed that Rosa roxburghii Tratt fruit is rich in phenolic acids, and that it exerted lipid lowering effects in the hyperlipidemic rats.
摘要
背景
刺梨果实因其独特的生物活性在中国被广泛用作药食两用资源。在本研究中，我们旨在表征其酚酸成分，并研究该植物在高脂血症大鼠模型中的潜在降血脂作用。
方法
我们评估了刺梨果实水醇提取物（HRT）对高脂血症大鼠血清脂质、体重、脂蛋白代谢和抗氧化酶活性以及脂质代谢基因表达的影响。
结果
HRT显著降低了高脂血症大鼠的体重增加，并降低了血清和肝脏脂质水平。此外，HRT处理提高了抗氧化酶、脂蛋白脂肪酶和肝脂肪酶的活性，下调了肝脏组织中固醇调节元件结合蛋白1c和乙酰辅酶A羧化酶的mRNA和蛋白表达，并上调了过氧化物酶体增殖物激活受体α和低密度脂蛋白受体的mRNA和蛋白表达。
结论
结果表明，刺梨果实富含酚酸，并且在高脂血症大鼠中具有降血脂作用。
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