Xu Yuyan, Sun Baofei, Zeng Qibing, Wei Shaofeng, Yang Guanghong, Zhang Aihua
The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education & School of Public Health, Guizhou Medical University, Guiyang, China.
Front Pharmacol. 2022 Apr 25;13:819472. doi: 10.3389/fphar.2022.819472. eCollection 2022.
Endemic arsenism caused by coal burning is a unique type of biogeochemical disease that only exists in China, and it is also a disease of element imbalances. Previous studies have shown that element imbalances are involved in the pathogenesis of arsenic; however, the interaction between the various elements and effective preventive measures have not been fully studied. This study first conducted a cross-sectional study of a total of 365 participants. The results showed that arsenic exposure can increase the content of elements (Al, As, Fe, Hg, K, and Na) in the hair ( 0.05), but the content of other elements (Ca, Co, Cu, Mn, Mo, P, Se, Sr, V, and Zn) was significantly decreased ( 0.05). Also, the high level of As, Fe, and Pb and the low level of Se can increase the risk of arsenism ( 0.05). Further study found that the combined exposure of Fe-As and Pb-As can increase the risk of arsenism, but the combined exposure of Se-As can reduce the risk of arsenism ( 0.05). In particular, a randomized, controlled, double-blind intervention study reveals that Tratt juice () can reverse the abovementioned element imbalances (the high level of Al, As, and Fe and the low level of Cu, Mn, Se, Sr, and Zn) caused by arsenic ( 0.05). Our study provides some limited evidence that the element imbalances (the high level of As, Fe, and Pb and the low level of Se) are the risk factors for the occurrences of arsenism. The second major finding was that can regulate the element imbalances, which is expected to improve arsenism. This study provides a scientific basis for further understanding a possible traditional Chinese health food, , as a more effective detoxication of arsenism.
燃煤型地方性砷中毒是中国特有的一种生物地球化学性疾病，也是一种元素失衡性疾病。以往研究表明，元素失衡参与了砷的发病机制；然而，各种元素之间的相互作用及有效的预防措施尚未得到充分研究。本研究首先对365名参与者进行了横断面研究。结果表明，砷暴露可增加头发中元素（铝、砷、铁、汞、钾和钠）的含量（P<0.05），但其他元素（钙、钴、铜、锰、钼、磷、硒、锶、钒和锌）的含量显著降低（P<0.05）。此外，高砷、高铁和高铅以及低硒水平会增加砷中毒的风险（P<0.05）。进一步研究发现，铁-砷和铅-砷联合暴露会增加砷中毒风险，但硒-砷联合暴露可降低砷中毒风险（P<0.05）。特别是，一项随机、对照、双盲干预研究表明，Tratt汁（）可逆转由砷引起的上述元素失衡（高铝、高砷和高铁以及低铜、低锰、低硒、低锶和低锌）（P<0.05）。我们的研究提供了一些有限的证据，表明元素失衡（高砷、高铁和高铅以及低硒）是砷中毒发生的危险因素。第二个主要发现是，（）可以调节元素失衡，有望改善砷中毒。本研究为进一步了解一种可能的传统中国保健食品（）作为更有效的砷中毒解毒剂提供了科学依据。
