Seob Lim Kyung, Park Jun-Kyu, Ho Jeong Myung, Ho Bae In, Sung Park Dae, Won Shim Jae, Ha Kim Jung, Kuk Kim Hyun, Soo Kim Sung, Sun Sim Doo, Joon Hong Young, Han Kim Ju, Ahn Youngkeun
Korea Cardiovascular Stent Institute, Jangsung.
Cardiovascular Convergence Research Center, Nominated by the Korea Ministry of Health and Welfare.
Acta Cardiol Sin. 2018 May;34(3):224-232. doi: 10.6515/ACS.201805_34(3).20171204A.
Gallic acid (3,4,5-trihydroxybenzoic acid) is a natural polyphenol and strong natural antioxidant found abundantly in red wine and green tea. The aim of this study was to examine the anti-inflammatory effect of a novel gallic acid-eluting stent in a porcine coronary restenosis model.
Fifteen pigs were randomized into three groups; in which a total of 30 coronary arteries (10 in each group) were implanted with gallic acid-eluting stents (GESs, n = 10), gallic acid and sirolimus-eluting stents (GSESs, n = 10), or sirolimus-eluting stents (SESs, n = 10). Histopathologic analysis was performed 28 days after stenting.
There were no significant differences in injury score and fibrin score among the groups, however there were significant differences in the internal elastic lamina (4.0 ± 0.83 mm in GES vs. 3.0 ± 0.53 mm in GSES vs. 4.6 ± 1.43 mm in SES, p < 0.0001), lumen area (2.3 ± 0.49 mm in GES vs. 1.9 ± 0.67 mm in GSES vs. 2.9 ± 0.56 mm in SES, p < 0.0001), neointimal area (1.7 ± 0.63 mm in GES vs. 1.1 ± 0.28 mm in GSES vs. 1.7 ± 1.17 mm in SES, p < 0.05), and percent area of stenosis (42.4% ± 9.22% in GES vs. 38.2% ± 12.77% in GSES vs. 33.9% ± 15.64% in SES, p < 0.05). The inflammation score was significantly lower in the GES and GSES groups compared to that in the SES group [1.0 (range: 1.0 to 2.0) in GES vs. 1.0 (range: 1.0 to 1.0) in GSES vs. 1.5 (range: 1.0 to 3.0) in SES, p < 0.05].
The GES group had a greater percent area of stenosis than the SES group. Although gallic acid in the GES and GSES groups did not show a synergistic effect in suppressing neointimal hyperplasia, it resulted in greater inhibition of the inflammatory reaction in the porcine coronary restenosis model than in the SES group.
没食子酸（3,4,5 - 三羟基苯甲酸）是一种天然多酚和强天然抗氧化剂，大量存在于红酒和绿茶中。本研究的目的是在猪冠状动脉再狭窄模型中研究新型没食子酸洗脱支架的抗炎作用。
15头猪被随机分为三组；总共30条冠状动脉（每组10条）分别植入没食子酸洗脱支架（GES，n = 10）、没食子酸与西罗莫司洗脱支架（GSES，n = 10）或西罗莫司洗脱支架（SES，n = 10）。支架置入28天后进行组织病理学分析。
各组间损伤评分和纤维蛋白评分无显著差异，但内弹力膜（GES组为4.0±0.83mm，GSES组为3.0±0.53mm，SES组为4.6±1.43mm，p < 0.0001）、管腔面积（GES组为2.3±0.49mm，GSES组为1.9±0.67mm，SES组为2.9±0.56mm，p < 0.0001）、新生内膜面积（GES组为1.7±0.63mm，GSES组为1.1±0.28mm，SES组为1.7±1.17mm，p < 0.05）和狭窄面积百分比（GES组为42.4%±9.22%，GSES组为38.2%±12.77%，SES组为33.9%±15.64%，p < 0.05）存在显著差异。GES组和GSES组的炎症评分显著低于SES组[GES组为1.0（范围：1.0至2.0），GSES组为1.0（范围：1.0至1.0），SES组为1.5（范围：1.0至3.0），p < 0.05]。
GES组的狭窄面积百分比高于SES组。虽然GES组和GSES组中的没食子酸在抑制新生内膜增生方面未显示协同作用，但在猪冠状动脉再狭窄模型中，其对炎症反应的抑制作用比SES组更强。
