Greco Renata, Muretti Mirko, Djordjevic Jasmina, Jin Xu Yu, Hill Elaine, Renna Maurizio, Petrou Mario
Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Department of Cardiac Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Open Heart. 2020 Mar 15;7(1):e001209. doi: 10.1136/openhrt-2019-001209. eCollection 2020.
Re-do aortic valve surgery carries a higher mortality and morbidity compared with first time aortic valve replacement (AVR) and often requires concomitant complex procedures. Transcatheter aortic valve replacement (TAVR) is an option for selective patients. The aim of this study is to present our experience with re-do aortic valve procedures and give an insight into the characteristics of these patients and their outcomes.
Retrospective review of 80 consecutive re-do aortic valve procedures.
Mean patients' age was 51.80±18.73 years. Aortic regurgitation (AR) was present in 51 (65.4%) patients and aortic stenosis (AS) in 38 (48.7%). Indications for reoperation were: infective endocarditis (IE) (23.8%), bioprosthetic degeneration (12.5%), mechanical valve dysfunction (5%), paravalvular leak (6.2%), patient-prosthesis mismatch (3.8%), native valve disease (25%), aortic aneurysm, pseudoaneurysm and dissection (35%), aortic root/homograft degeneration (27.5%). Forty-one (51.2%) patients underwent re-do AVR, 39 (48.8%) re-do complex aortic valve surgery (28 root, 23 ascending aorta and 6 hemiarch procedures) and 37.5% concomitant procedures. A bioprosthesis was implanted in 43.8%, a mechanical valve in 37.5%, a composite graft in 2.5%, a Biovalsalva graft in 6.2% and a homograft in 10% of patients. In-hospital mortality was 3.8% and incidence of major complications was low.
A significant proportion of patients were young (61%<60 y), required complex aortic procedures (49%) or presented with contraindications for TAVR (mechanical valve, AR, IE, proximal aortic disease, need for concomitant surgery). Re-do aortic surgery remains the only treatment for such challenging cases and can be performed with acceptable mortality and morbidity in a specialised aortic centre.
与首次主动脉瓣置换术(AVR)相比,再次主动脉瓣手术的死亡率和发病率更高,且常常需要同期进行复杂手术。经导管主动脉瓣置换术(TAVR)是部分患者的一种选择。本研究旨在介绍我们在再次主动脉瓣手术方面的经验,并深入了解这些患者的特征及其手术结果。
对连续80例再次主动脉瓣手术进行回顾性分析。
患者平均年龄为51.80±18.73岁。51例(65.4%)患者存在主动脉瓣关闭不全(AR),38例(48.7%)存在主动脉瓣狭窄(AS)。再次手术的指征包括:感染性心内膜炎(IE)(23.8%)、生物瓣退变(12.5%)、机械瓣功能障碍(5%)、瓣周漏(6.2%)、人工瓣膜-患者不匹配(3.8%)、自体瓣膜疾病(25%)、主动脉瘤、假性动脉瘤和夹层(35%)、主动脉根部/同种异体移植物退变(27.5%)。41例(51.2%)患者接受了再次AVR,39例(48.8%)接受了再次复杂主动脉瓣手术(28例根部手术、23例升主动脉手术和6例半弓手术),37.5%的患者进行了同期手术。43.8%的患者植入了生物瓣,37.5%植入了机械瓣,2.5%植入了复合移植物,6.2%植入了Biovalsalva移植物,10%植入了同种异体移植物。住院死亡率为3.8%,主要并发症发生率较低。
相当一部分患者较为年轻(61%<60岁),需要进行复杂的主动脉手术(49%)或存在TAVR的禁忌证(机械瓣、AR、IE、主动脉近端疾病、需要同期手术)。再次主动脉手术仍然是此类具有挑战性病例的唯一治疗方法,在专业的主动脉中心进行手术,死亡率和发病率可接受。