Dhanekula Arjune S, Nishath Thamanna, Aldea Garbiel S, Burke Christopher R
Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Wash.
University of Washington School of Medicine, Seattle, Wash.
JTCVS Tech. 2022 Feb 26;13:31-39. doi: 10.1016/j.xjtc.2022.02.025. eCollection 2022 Jun.
Management of degenerated bioprosthetic aortic valves remains a challenge. Valve-in-valve transcatheter aortic valve replacement (AVR) has limited utility in the presence of small annuli/prosthetic valves. Sutureless valves may offer an advantage over traditional redo AVR by maximizing effective orifice area due to their unique design as well as ease of implant.
Twenty-two patients undergoing redo AVR received a sutureless valve in our institution over the past 5 years. All patients were determined to be poor candidates for valve-in-valve transcatheter AVR due to a combination of small annulus size, low coronary heights, and/or underlying valve characteristics (ie, mechanical valves).
Median time from implant to redo AVR was 8 years. One patient died within 30 days. In the 13 patients who had a 21 mm or smaller valve explanted, 5 small, 7 medium, and 1 large Perceval valves were implanted (all with larger internal diameters than the explanted valve). The average postoperative gradient of the cohort valves was 14.8 mm Hg compared with 38.8 mm Hg preoperatively.
In addition to their ease of use and rapid deployment, sutureless bioprosthetic aortic valves offer significant physiological advantages in patients with degenerated prosthetic aortic valves and small anatomical annuli. It can also simplify the surgical approach to redo AVR following a Bentall procedure. If long-term durability is confirmed, sutureless valves should be considered in a broader population of patients for both redo and primary aortic valve replacement surgery.
退化生物人工主动脉瓣的管理仍然是一项挑战。在瓣环较小/人工瓣膜存在的情况下,瓣中瓣经导管主动脉瓣置换术(AVR)的效用有限。无缝合瓣膜由于其独特设计以及植入简便,在有效瓣口面积最大化方面可能比传统再次AVR具有优势。
在过去5年中,我们机构有22例接受再次AVR的患者接受了无缝合瓣膜。由于瓣环尺寸小、冠状动脉高度低和/或潜在瓣膜特征(即机械瓣膜)的综合因素,所有患者均被确定为瓣中瓣经导管AVR的不佳候选者。
从植入到再次AVR的中位时间为8年。1例患者在30天内死亡。在13例植入21毫米或更小瓣膜的患者中,植入了5个小号、7个中号和1个大号Perceval瓣膜(所有内径均大于取出的瓣膜)。该队列瓣膜术后平均梯度为14.8毫米汞柱,而术前为38.8毫米汞柱。
除了使用方便和部署迅速外,无缝合生物人工主动脉瓣在退化人工主动脉瓣和解剖瓣环较小的患者中具有显著的生理优势。它还可以简化Bentall手术后再次AVR的手术方法。如果长期耐久性得到证实,对于再次手术和初次主动脉瓣置换手术的更广泛患者群体,应考虑使用无缝合瓣膜。