关于“无雌性”基因座参与果蝇性别决定的遗传学证据。
Genetic evidence that the sans fille locus is involved in Drosophila sex determination.
作者信息
Oliver B, Perrimon N, Mahowald A P
机构信息
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
出版信息
Genetics. 1988 Sep;120(1):159-71. doi: 10.1093/genetics/120.1.159.
Abstract
Females homozygous for sans fille1621 (= fs(1)1621) have an abnormal germ line. Instead of producing eggs, the germ-line cells proliferate forming ovarian tumors or excessive numbers of nurse cells. The Sex-lethal gene product(s) regulate the branch point of the dosage compensation and sex determination pathways in the soma. The role of Sex-lethal in the germ line is not clear but the germ line of females homozygous for female sterile Sex-lethal alleles or germ-line clones of loss-of-function alleles are characterized by ovarian tumors. Females heterozygous for sans fille1621 or Sex-lethal are phenotypically wild type with respect to viability and fertility but females trans-heterozygous for sans fille1621 and Sex-lethal show ovarian tumors, somatic sexual transformations, and greatly reduced viability.
摘要
无女儿1621（= fs(1)1621）纯合的雌性个体具有异常的生殖系。生殖系细胞不产生卵子，而是增殖形成卵巢肿瘤或大量滋养细胞。性致死基因产物调节躯体中剂量补偿和性别决定途径的分支点。性致死基因在生殖系中的作用尚不清楚，但雌性不育性致死等位基因纯合的雌性个体的生殖系或功能丧失等位基因的生殖系克隆的特征是卵巢肿瘤。无女儿1621或性致死基因杂合的雌性个体在活力和生育力方面表现为野生型表型，但无女儿1621和性致死基因反式杂合的雌性个体表现出卵巢肿瘤、体细胞性转变和活力大大降低。
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