评估冠心病合并 2 型糖尿病患者 CTRP5 及炎症标志物水平变化模式。
Evaluation of changing the pattern of CTRP5 and inflammatory markers levels in patients with coronary artery disease and type 2 diabetes mellitus.
机构信息
Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Arch Physiol Biochem. 2022 Aug;128(4):964-969. doi: 10.1080/13813455.2020.1742164. Epub 2020 Mar 23.
PURPOSE
It has recently found that adipokines, play a numerous functional roles in inflammation, lipids and glucose metabolism and in the pathogenically conditions such as atherosclerosis and insulin resistance. Therefore, for the first time we aimed the present study to evaluating serum levels of CTRP5 and inflammatory cytokines patients with CAD and T2DM in comparison with controls.
METHODS
This study was done on 44 patients with CAD, 45 type 2 diabetes mellitus (T2DM), 41 CAD + T2DM and 41 controls. Serum levels of TNF-α, IL-6, MCP-1 and CTRP5 were investigated by ELISA method.
RESULTS
The CTRP5 levels of all patients groups were lower in comparison with control group. There was a significant negative relationship between CTRP5 levels and cytokines concentration in the studied patients.
CONCLUSIONS
Our findings suggested a potential role of CTRP5 in inflammatory process of underlying atherosclerosis and diabetes; however, more studies are needed to support these finding.
目的
最近发现脂肪细胞因子在炎症、脂质和糖代谢以及动脉粥样硬化和胰岛素抵抗等病理情况下发挥着众多功能作用。因此，我们首次旨在评估 CAD 和 T2DM 患者与对照组相比的血清 CTRP5 和炎症细胞因子水平。
方法
本研究纳入了 44 例 CAD 患者、45 例 2 型糖尿病（T2DM）患者、41 例 CAD+T2DM 患者和 41 例对照组。采用 ELISA 法检测 TNF-α、IL-6、MCP-1 和 CTRP5 的血清水平。
结果
所有患者组的 CTRP5 水平均低于对照组。在研究患者中，CTRP5 水平与细胞因子浓度呈显著负相关。
结论
我们的研究结果表明 CTRP5 在潜在的动脉粥样硬化和糖尿病炎症过程中可能发挥作用；然而，还需要更多的研究来支持这些发现。
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