饮食炎症指数与膀胱癌风险：一项前瞻性研究。

Dietary inflammatory index and bladder cancer risk: a prospective study.

机构信息

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.

Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA.

出版信息

Eur J Clin Nutr. 2020 Oct;74(10):1428-1433. doi: 10.1038/s41430-020-0602-y. Epub 2020 Mar 19.

DOI:10.1038/s41430-020-0602-y

PMID:32203237

Abstract

BACKGROUND

Dietary factors may play a role in bladder cancer etiology through modulation of inflammation. The purpose of this study was to examine the relationship between the inflammatory potential of diet, as estimated by the Dietary Inflammatory Index (DII), and bladder cancer risk.

METHODS

Energy-adjusted DII (E-DII) scores were computed among 101,721 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis stratified by sex, with adjustment for smoking status and other confounding.

RESULTS

Over a median of 12.5 years of follow-up, 776 bladder cancer cases were diagnosed. E-DII scores were not associated with bladder cancer risk in the multivariable models. The HRs (95% CIs) in the highest compared with the lowest E-DII quintile were 0.90 (0.70-1.17) and 1.22 (0.72-2.06) for men and women, respectively. The associations did not differ when DII score was set as a continuous variable. The HRs (95% CIs) of one-unit increment in the E-DII for bladder cancer risk were 0.99 (0.96-1.02) and 1.01 (0.94-1.10) for men and women, respectively.

CONCLUSIONS

Our study does not support an association between inflammatory potential of diet, as estimated by the E-DII, and bladder cancer risk.

摘要

背景

饮食因素可能通过调节炎症在膀胱癌发病机制中起作用。本研究旨在研究饮食的炎症潜力（通过饮食炎症指数[DII]来估计）与膀胱癌风险之间的关系。

方法

在前列腺癌、肺癌、结直肠癌和卵巢癌（PLCO）研究中，对 101721 名参与者进行了能量调整的 DII（E-DII）评分计算。使用 Cox 回归分析按性别分层，调整吸烟状况和其他混杂因素，估计危险比（HR）和 95%置信区间（CI）。

结果

在中位 12.5 年的随访期间，诊断出 776 例膀胱癌病例。在多变量模型中，E-DII 评分与膀胱癌风险无关。与最低 E-DII 五分位数相比，最高 E-DII 五分位数的 HR（95%CI）分别为男性 0.90（0.70-1.17）和女性 1.22（0.72-2.06）。当 DII 评分设为连续变量时，关联没有差异。E-DII 每增加一个单位，男性和女性膀胱癌风险的 HR（95%CI）分别为 0.99（0.96-1.02）和 1.01（0.94-1.10）。