Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Cancer Epidemiol Biomarkers Prev. 2023 Dec 1;32(12):1726-1733. doi: 10.1158/1055-9965.EPI-23-0690.
This study aimed to explore the relationship between diabetes risk reduction diet (DRRD) and bladder cancer risk in Prostate, Lung, Colorectal, Ovarian (PLCO) cohort.
Data from 99,001 participants in the PLCO Cancer Screening Trial were analyzed using Cox proportional hazards regression models to estimate HRs and 95% confidence intervals (CI) for the association between DRRD score and bladder cancer incidence. Subgroup analyses were conducted to assess whether variables such as age, sex, body mass index, cigarette smoking status, and history of diabetes influenced the observed association. The DRRD score was formulated on the basis of nine nutrient intake indicators derived from the Dietary History Questionnaire.
During the median follow-up of 11.7 years, 761 new bladder cancer cases were identified. Participants with highest DRRD scores exhibited a reduced risk of bladder cancer compared with those in the lowest quartile (unadjusted analysis, HR, 0.65; 95% CI, 0.53-0.82); multivariable adjusted analysis, HR, 0.79; 95% CI, 0.64-0.98; Ptrend = 0.007). A similar risk reduction was seen solely in transitional cell carcinoma (HR, 0.79; 95% CI, 0.64-0.99; P = 0.007). In addition, the significant negative association between DRRD scores and bladder cancer risk persisted even after excluding participants with unique characteristics.
This large prospective population-based study suggests that adherence to a DRRD may contribute to the prevention of bladder cancer.
The DRRD could potentially mitigate bladder cancer risk, which warrants further validation in diverse populations.
本研究旨在探讨前列腺、肺、结肠、卵巢（PLCO）队列中糖尿病风险降低饮食（DRRD）与膀胱癌风险之间的关系。
使用 Cox 比例风险回归模型分析来自 PLCO 癌症筛查试验的 99001 名参与者的数据，以估计 DRRD 评分与膀胱癌发病率之间的关联的 HRs 和 95%置信区间（CI）。进行亚组分析以评估年龄、性别、体重指数、吸烟状况和糖尿病史等变量是否影响观察到的关联。DRRD 评分是基于从饮食史问卷中得出的九个营养素摄入量指标制定的。
在中位数为 11.7 年的随访期间，确定了 761 例新的膀胱癌病例。与最低四分位数相比，DRRD 评分最高的参与者患膀胱癌的风险降低（未调整分析，HR，0.65；95%CI，0.53-0.82；多变量调整分析，HR，0.79；95%CI，0.64-0.98；Ptrend = 0.007）。仅在移行细胞癌中观察到类似的风险降低（HR，0.79；95%CI，0.64-0.99；P = 0.007）。此外，即使在排除具有独特特征的参与者后，DRRD 评分与膀胱癌风险之间的显著负相关关系仍然存在。
这项大型前瞻性基于人群的研究表明，遵循 DRRD 可能有助于预防膀胱癌。
DRRD 可能潜在地降低膀胱癌风险，这需要在不同人群中进一步验证。
