Shahsavari Maryam, Azizi Mazreah Siavash, Arbabi Kalati Parvin
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Zahedan University of Medical Sciences, Zahedan, Iran.
School of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.
Minerva Stomatol. 2020 Jun;69(3):127-132. doi: 10.23736/S0026-4970.20.04269-7. Epub 2020 Mar 20.
Aggressive periodontitis is a progressive disease that can cause tooth loss within a short period of time. Mast cells are found in tissues with various allergic and inflammatory conditions including periodontal disease through the release of cytokines, chemokines, and proteolytic enzymes. Given the findings of some studies on the related role of mast cells, this study was conducted to determine the number of mast cells in aggressive periodontitis.
This study was conducted on 30 participants divided into two groups visiting the Faculty of Dentistry of University of Medical Sciences. A total of 15 participants with aggressive periodontitis and 15 healthy participants were investigated. For counting mast cells, toluidine blue staining was used. The percentage of mast cells and demographic factors were evaluated in the two groups and the results were analyzed in SPSS using descriptive statistics and independent t-tests. A P value <0.05 was considered significant.
The mean percentage of mast cells in the aggressive periodontitis group was 27.1±8.9 which was significantly higher than that of the healthy group, i.e. 12.6±5.1 (P<0.001).
In general, the results of the study showed that the percentage of mast cells in the aggressive periodontitis group was more than two times higher than that of the healthy group, which is indicative of an increase in the number of mast cells in aggressive periodontitis disease.
侵袭性牙周炎是一种进展性疾病，可在短时间内导致牙齿脱落。肥大细胞存在于包括牙周病在内的各种过敏和炎症性疾病的组织中，通过释放细胞因子、趋化因子和蛋白水解酶发挥作用。鉴于一些关于肥大细胞相关作用的研究结果，本研究旨在确定侵袭性牙周炎中肥大细胞的数量。
本研究对30名参与者进行，这些参与者分为两组，均来自医科大学牙科学院。共调查了15名侵袭性牙周炎患者和15名健康参与者。采用甲苯胺蓝染色法计数肥大细胞。评估两组肥大细胞的百分比和人口统计学因素，并使用描述性统计和独立t检验在SPSS中分析结果。P值<0.05被认为具有统计学意义。
侵袭性牙周炎组肥大细胞的平均百分比为27.1±8.9，显著高于健康组，即12.6±5.1（P<0.001）。
总体而言，研究结果表明，侵袭性牙周炎组肥大细胞的百分比比健康组高出两倍多，这表明侵袭性牙周炎疾病中肥大细胞数量增加。
