Fattahi Shirin, Sadighi Mehrnoosh, Faramarzi Masoume, Karimifard Elham, Mirzaie Amirali
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
J Adv Periodontol Implant Dent. 2019 Aug 31;11(1):34-38. doi: 10.15171/japid.2019.006. eCollection 2019.
The role of mast cells in periodontal tissue degradation has been established. These cells can be efficient in the etiology of periodontitis by participating in gingival homeostasis and releasing cytokines and enzymes, resulting in connective tissue matrix breakdown. Therefore, the aim of this study was to compare the mast cell counts between patients with moderate and severe periodontitis.
This case‒control study was performed on 15 subjects with severe periodontitis and 15 subjects with moderate periodontitis, who needed periodontal surgical treatment. Incisional biopsies were provided during periodontal surgery. Afterward, the mean counts of mast cells were determined after toluidine blue staining of the samples. Finally, data were analyzed with SPSS.
The results of this study showed that mast cell counts in severe periodontitis cases were lower than those in moderate periodontitis. However, there were no statistically significant differences between the two groups (P=0.611). In addition, the mean mast cell counts in males and females did not show a statistically significant difference (P=0.231), although the count was higher in female subjects.
Based on the results, no statistically significant differences were found in mast cell counts between subjects with severe periodontitis and those with moderate periodontitis.
肥大细胞在牙周组织破坏中的作用已得到证实。这些细胞可通过参与牙龈内环境稳态并释放细胞因子和酶，在牙周炎的病因学中发挥作用，从而导致结缔组织基质分解。因此，本研究的目的是比较中度和重度牙周炎患者的肥大细胞计数。
本病例对照研究对15例需要进行牙周手术治疗的重度牙周炎患者和15例中度牙周炎患者进行。在牙周手术期间进行切口活检。之后，对样本进行甲苯胺蓝染色后确定肥大细胞的平均计数。最后，用SPSS对数据进行分析。
本研究结果显示，重度牙周炎病例中的肥大细胞计数低于中度牙周炎患者。然而，两组之间无统计学显著差异（P = 0.611）。此外，男性和女性的肥大细胞平均计数虽女性受试者的计数较高，但未显示出统计学显著差异（P = 0.231）。
基于这些结果，重度牙周炎患者和中度牙周炎患者之间的肥大细胞计数未发现统计学显著差异。
