Valet P, Damase-Michel C, Taouis M, Montastruc J L, Cotonat J, Montastruc P
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 317, Faculté de Médecine, Toulouse, France.
Fundam Clin Pharmacol. 1988;2(4):267-76. doi: 10.1111/j.1472-8206.1988.tb00638.x.
The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2-fold for noradrenaline and 16.7-fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2- and leukocyte beta-adrenoreceptors is not submitted to short-term regulation, at least by endogenous catecholamines in dogs.
通过急性去窦主动脉神经支配（ASAD）建立神经源性高血压模型，研究内源性儿茶酚胺急性释放对犬血小板α2和白细胞β肾上腺素能受体以及代谢指标（葡萄糖和游离脂肪酸）的影响。尽管儿茶酚胺水平显著升高（例如，ASAD后45分钟时去甲肾上腺素升高4.2倍，肾上腺素升高16.7倍）以及血糖水平升高，游离脂肪酸血浆水平显著降低，但在整个实验过程中未观察到血小板α2或白细胞β肾上腺素能受体结合位点（数量和亲和力）有变化。提示犬血小板α2和白细胞β肾上腺素能受体的数量至少在短期内不受内源性儿茶酚胺的调节。
