Department of Obstetrics and Gynecology, University of Chieti, 66100 Chieti, Italy.
Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Int J Mol Sci. 2020 Mar 19;21(6):2120. doi: 10.3390/ijms21062120.
Extracellular vesicles (EVs) actively participate in inter-cellular crosstalk and have progressively emerged as key players of organized communities of cells within multicellular organisms in health and disease. For these reasons, EVs are attracting the attention of many investigators across different biomedical fields. In this scenario, the possibility to study specific placental-derived EVs in the maternal peripheral blood may open novel perspectives in the development of new early biomarkers for major obstetric pathological conditions. Here we reviewed the involvement of EVs in feto-maternal crosstalk mechanisms, both in physiological and pathological conditions (preeclampsia, fetal growth restriction, preterm labor, gestational diabetes mellitus), also underlining the usefulness of EV characterization in maternal-fetal medicine.
细胞外囊泡（EVs）积极参与细胞间通讯，并逐渐成为多细胞生物中细胞群落的关键参与者，在健康和疾病中都发挥着重要作用。由于这些原因，EVs 引起了许多不同的生物医学领域的研究人员的关注。在这种情况下，研究母体外周血中特定胎盘来源的 EVs 的可能性可能为主要产科病理情况的新早期生物标志物的发展开辟新的前景。在这里，我们综述了 EVs 在胎儿-母体通讯机制中的作用，包括生理和病理条件（子痫前期、胎儿生长受限、早产、妊娠期糖尿病），同时强调了 EV 特征在母婴医学中的有用性。
