He Xiaojing, Liu Shiqi, Wang Yudi, Du Hualongyue, Lin Qiaoxi, Wang Wenhui, Ou Zihao, Zheng Lei
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Sci China Life Sci. 2025 Jul 11. doi: 10.1007/s11427-024-2937-4.
The discovery of extracellular vesicles (EVs), including exosomes, microvesicles, and shedding vesicles, signifies a paradigm shift in our understanding of cellular communication and a variety of biological processes, encompassing immune regulation, disease pathogenesis, and tissue repair. Particularly in the realm of pregnancy-related diseases, EVs have unveiled new perspectives and tools for deciphering the molecular mechanisms underlying pregnancy and its associated disorders. Emerging evidence indicates the multifaceted role of EVs in placental formation, regulation of maternal-fetal immune balance, and the development of pregnancy complications. The review aims to synthesize current research findings on the potential applications of EVs in pregnancy diseases and may help identify the EVs as diagnostic or therapeutic strategies for pregnancy-related disorders.
细胞外囊泡（EVs）的发现，包括外泌体、微囊泡和脱落囊泡，标志着我们对细胞通讯以及包括免疫调节、疾病发病机制和组织修复在内的各种生物学过程的理解发生了范式转变。特别是在妊娠相关疾病领域，细胞外囊泡为解读妊娠及其相关疾病背后的分子机制提供了新的视角和工具。新出现的证据表明，细胞外囊泡在胎盘形成、母胎免疫平衡调节以及妊娠并发症的发展中具有多方面的作用。本综述旨在综合目前关于细胞外囊泡在妊娠疾病中潜在应用的研究结果，并可能有助于将细胞外囊泡确定为妊娠相关疾病的诊断或治疗策略。
