Ooms Ariadne H A G, Vujanić Gordan M, D'Hooghe Ellen, Collini Paola, L'Herminé-Coulomb Aurore, Vokuhl Christian, Graf Norbert, Heuvel-Eibrink Marry M van den, de Krijger Ronald R
Princess Máxima Center for pediatric oncology, 3584 CS Utrecht, The Netherlands.
Pathan B.V., 3045 PM Rotterdam, The Netherlands.
Cancers (Basel). 2020 Mar 19;12(3):729. doi: 10.3390/cancers12030729.
Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.
肾肿瘤约占儿童所有恶性肿瘤的7%。这是一组高度异质性的肿瘤，每种肿瘤都有其独特的治疗管理、预后情况以及与胚系易感性的关联。组织病理学是确立正确诊断的关键，因此需要有儿科肿瘤学专业知识的病理学家来处理这些罕见肿瘤。虽然每种肿瘤都呈现出不同的组织学特征，但它们在细胞类型和组织学模式上确实有相当大的重叠，如果仅基于常规组织学，很难做出诊断。为此，免疫组织化学和分子分析等辅助技术对于正确诊断可能非常重要，从而实现恰当的治疗。为了经济高效地使用辅助技术，我们提出一种基于模式的方法，并提供建议，以帮助决定需要哪些抗体组合，并辅以一部分基因的分子特征分析。
