Laboratório de Imunopatologia Keizo Asami - LIKA, Centro de Biociências, Universidade Federal de Pernambuco (UFPE) , Recife, Pernambuco, Brazil.
Laboratório de Biologia Molecular E Expressão Gênica - LABMEG, Universidade Federal de Alagoas (UFAL) - Campus Arapiraca , Arapiraca, Alagoas, Brazil.
Immunol Invest. 2021 Jan;50(1):58-79. doi: 10.1080/08820139.2020.1733011. Epub 2020 Mar 24.
: Chikungunya virus (CHIKV) is a global concern, inducing chikungunya fever and trigging an arthritogenic chronic phase beyond some severe forms. Outcomes of CHIKV infections in humans are dependent on genetic variations. Here, a systematic review was performed to show evidence of genetic variations on infection outcomes of patients. : Searches were performed in Scopus, SciELO, MEDLINE/PubMed, Web of Science, OneFile (GALE), Periódicos CAPES and ScienceDirect Journals databases. The PICOS approach was used to assess the eligibility of records. A meta-analysis was also conducted to show an association between described alleles/genes and CHIKV infection outcome. : Reviews of genetic variants were conducted on genes: and . Studies were performed on Gabon, Singapore, and India, including Indians, Malay, Gabonese and Chinese ethnicities and published between 2009-2017. The meta-analysis was performed with *01; *03; *04; *07; *10; *11; *13; *14 and *15 and *02; *03; *05 and *06 alleles with Indian population sample. Sampling power was >80% and a significant positive association between *14 and CHIKV infection was found (OR = 1.67, 95% CI = 1.04-2.67; = .03). : Majority of the studies were conducted in India. Meta-analysis suggests that *14 is related to the susceptibility of symptomatic CHIKV infection in Indian population. The literature about CHIKV infection and genetic variations is scarce. The precise role of genetic variation in CHIKV is not clear yet. Further studies are necessary to provide more concrete evidences.
基孔肯雅热病毒（CHIKV）是一个全球性的关注点，可引起基孔肯雅热，并在某些严重形式后引发关节病慢性期。人类感染 CHIKV 的结果取决于遗传变异。本研究通过系统评价来展示患者感染结果的遗传变异证据。在 Scopus、SciELO、MEDLINE/PubMed、Web of Science、OneFile（GALE）、CAPES 期刊和 ScienceDirect 期刊数据库中进行了检索。采用 PICOS 方法评估记录的合格性。还进行了荟萃分析，以显示描述的等位基因/基因与 CHIKV 感染结果之间的关联。对基因和进行了遗传变异综述。研究在加蓬、新加坡和印度进行，包括印度人、马来人、加蓬人和中国人，发表时间为 2009-2017 年。荟萃分析使用印度人群样本的*01；*03；*04；*07；*10；*11；13；14 和15 和02；03；05 和06 等位基因进行。抽样能力>80%，发现14 与 CHIKV 感染之间存在显著正相关（OR=1.67，95%CI=1.04-2.67；=0.03）。大多数研究在印度进行。荟萃分析表明，*14 与印度人群中症状性 CHIKV 感染的易感性有关。关于 CHIKV 感染和遗传变异的文献很少。遗传变异在 CHIKV 中的精确作用尚不清楚。需要进一步的研究来提供更具体的证据。
