Wu Shi-Yan, Zhang Hua, Wu Wen, Wu Yi-Yang
Department of Pediatrics, Sanya Central Hospital/Third People's Hospital of Hainan Province, Sanya, Hainan 572000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Mar;22(3):269-273. doi: 10.7499/j.issn.1008-8830.2020.03.016.
To study the value of serum miR-21-3p combined with serum creatinine (Scr), cystatin C (Cys-C), and kidney injury molecule-1 (KIM-1) in predicting acute kidney injury (AKI) in children with sepsis.
A total of 142 children who were diagnosed with sepsis from January 2016 to March 2019 were enrolled. According to the presence or absence of AKI, they were divided into AKI group with 49 children and non-AKI group with 93 children. The serum levels of miR-21-3p, Scr, Cys-C, and KIM-1 were measured for the two groups. The receiver operating characteristic (ROC) curve was plotted to analyze the value of serum miR-21-3p, Scr, Cys-C, and KIM-1 in predicting AKI. A Pearson correlation analysis was used to evaluate the correlation of serum miR-21-3p with Scr, Cys-C, and KIM-1.
The AKI group had significantly higher serum levels of miR-21-3p, Scr, Cys-C, and KIM-1 than the non-AKI group (P<0.05). The ROC curve analysis showed that the combination of serum miR-21-3p, Scr, Cys-C, and KIM-1 had an area under the ROC curve (AUC) of 0.962 (95%CI: 0.906-0.998), which was significantly larger than the AUC of each index alone (P<0.05), with a sensitivity of 97.0% and a specificity of 91.4%. The correlation analysis showed that the serum level of miR-21-3p was positively correlated with Scr, Cys-C, and KIM-1 in the AKI group (r=0.704, 0.812, and 0.863 respectively, P<0.01).
There is a significant increase in the serum level of miR-21-3p in children with sepsis and AKI, and its combination with Scr, Cys-C, and KIM-1 has a high value in predicting AKI.
探讨血清miR-21-3p联合血清肌酐（Scr）、胱抑素C（Cys-C）和肾损伤分子-1（KIM-1）对脓毒症患儿急性肾损伤（AKI）的预测价值。
选取2016年1月至2019年3月确诊为脓毒症的142例患儿。根据是否发生AKI，将其分为AKI组49例和非AKI组93例。检测两组患儿血清miR-21-3p、Scr、Cys-C和KIM-1水平。绘制受试者工作特征（ROC）曲线，分析血清miR-21-3p、Scr、Cys-C和KIM-1对AKI的预测价值。采用Pearson相关分析评估血清miR-21-3p与Scr、Cys-C和KIM-1的相关性。
AKI组血清miR-21-3p、Scr、Cys-C和KIM-1水平显著高于非AKI组（P<0.05）。ROC曲线分析显示，血清miR-21-3p、Scr、Cys-C和KIM-1联合检测的ROC曲线下面积（AUC）为0.962（95%CI：0.906-0.998），显著大于各指标单独检测的AUC（P<0.05），灵敏度为97.0%，特异度为91.4%。相关分析显示，AKI组血清miR-21-3p水平与Scr、Cys-C和KIM-1呈正相关（r分别为0.704、0.812和0.863，P<0.01）。
脓毒症合并AKI患儿血清miR-21-3p水平显著升高，其联合Scr、Cys-C和KIM-1对AKI具有较高的预测价值。
