Clinical Laboratory, 3201 Hospital, Hanzhong, Shaanxi, China.
Eur Rev Med Pharmacol Sci. 2018 Jul;22(14):4604-4610. doi: 10.26355/eurrev_201807_15518.
Acute kidney injury (AKI) is common in critically ill patients, and sepsis patients with AKI had a higher mortality rate. The aim of the present study was to determine the potential value of urinary miR-26b in the diagnosis of sepsis-associated AKI.
Urinary samples were collected from a cohort of 155 sepsis patients (68 AKI patients and 87 non-AKI patients) and 57 patients with non-infectious systemic inflammatory response syndrome (SIRS). The expression levels of urinary miR-26b were measured by RT-qPCR analysis. ROC curve analysis was performed to determine the diagnostic value. Pearson correlation analysis was performed to assess the levels of urinary miR-26b and several clinical parameters. Kaplan-Meier curves were plotted to show the impact of urinary miR-26b on the 28-day survival.
Significantly increased urinary miR-26b levels were found in patients with sepsis-associated AKI. Urinary miR-26b had a sensitivity of 90.8% and specificity of 75.0% for distinguishing between AKI sepsis and non-AKI sepsis. Urinary miR-26b levels were closely correlated with clinical parameters reflecting the severity of the disease. Kaplan-Meier analysis revealed that sepsis patients with high urinary miR-26b levels had an elevated mortality rate.
Taken together, these findings suggested that urinary miR-26b might be utilized as a potential biomarker for sepsis-associated AKI.
急性肾损伤（AKI）在危重症患者中较为常见，且伴有 AKI 的脓毒症患者死亡率更高。本研究旨在探讨尿 miR-26b 在诊断脓毒症相关性 AKI 中的潜在价值。
本研究纳入了 155 例脓毒症患者（68 例 AKI 患者和 87 例非 AKI 患者）和 57 例非感染性全身炎症反应综合征（SIRS）患者的尿液样本。采用 RT-qPCR 分析检测尿 miR-26b 的表达水平。通过 ROC 曲线分析评估其诊断价值。采用 Pearson 相关分析评估尿 miR-26b 与多项临床参数的相关性。绘制 Kaplan-Meier 曲线以显示尿 miR-26b 对 28 天生存率的影响。
与非 AKI 脓毒症患者相比，伴有 AKI 的脓毒症患者的尿 miR-26b 水平显著升高。尿 miR-26b 用于鉴别 AKI 脓毒症和非 AKI 脓毒症的敏感性为 90.8%，特异性为 75.0%。尿 miR-26b 水平与反映疾病严重程度的临床参数密切相关。Kaplan-Meier 分析显示，尿 miR-26b 水平较高的脓毒症患者死亡率较高。
综上所述，这些发现表明尿 miR-26b 可能可作为脓毒症相关性 AKI 的潜在生物标志物。
