Shah Tanay, Shah Niket, Vijay D G, Patel Bhavesh, Patel Samir
Surgical Oncology, HCG Cancer Hospital, S.g. Road, Ahmedabad, GJ 380060 India.
Indian J Surg Oncol. 2020 Mar;11(1):7-11. doi: 10.1007/s13193-019-01021-5. Epub 2019 Dec 18.
Male breast cancer is a rare tumour in all parts of the world. About 1% of all breast cancers occur in men. Occurrence of male breast cancer peaks at age 71 years. Familial cases usually have BRCA2 rather than BRCA1 mutations. Presentation is usually a lump or nipple inversion, but is often late, with more than 40% of individuals having stage III or IV disease. We retrospectively reviewed 25 male patients with breast cancer who came to the HCG Cancer Centre, Ahmedabad between 2014 and 2018, and their demographic details, tumor profile, and radiological, histopathological as well as luminal profile findings were studied. The average age at presentation and detection of male breast cancer was 61.08 years. Incidence of male ca. breast over these 4 years was 4.75/year which had a significant increase compared with our own data in the last 8 years (3/year). Male to female ratio for ca. breast was 1:61. One out of 25 (4%) patients had gynaecomastia. The most common histology was invasive ductal carcinoma-not otherwise specified with none of the patients having lobular carcinoma. Majority of patients were ER/PR positive and HER-2 negative. Male breast cancer is having a rising incidence, which in our study is 1.56%. Males have relatively older age at presentation and stage-by-stage treatment remains the same. Males are more likely to be having prognostically favourable luminal subtypes. Male breast cancer in Indian population is currently experiencing an increasing trend. Improved awareness amongst patients and high index of suspicion by the clinicians along with accurate diagnostic techniques help detect the disease at an earlier stage culminating into prolonged overall and disease-free survival.
男性乳腺癌在世界各地都是一种罕见肿瘤。所有乳腺癌病例中约1%发生在男性身上。男性乳腺癌的发病高峰在71岁。家族性病例通常存在BRCA2而非BRCA1基因突变。其临床表现通常为肿块或乳头内陷，但往往发现较晚，超过40%的患者患有III期或IV期疾病。我们回顾性研究了2014年至2018年间前往艾哈迈达巴德HCG癌症中心就诊的25例男性乳腺癌患者，对他们的人口统计学细节、肿瘤特征以及放射学、组织病理学和腔面特征结果进行了研究。男性乳腺癌患者就诊和确诊时的平均年龄为61.08岁。这4年中男性乳腺癌的发病率为每年4.75例，与我们过去8年的数据（每年3例）相比有显著增加。男性与女性乳腺癌的比例为1:61。25例患者中有1例（4%）患有男性乳房发育症。最常见的组织学类型是浸润性导管癌，非特殊类型，没有患者患有小叶癌。大多数患者雌激素受体/孕激素受体阳性，人表皮生长因子受体2阴性。男性乳腺癌的发病率正在上升，在我们的研究中为1.56%。男性就诊时年龄相对较大，分阶段治疗方式不变。男性更有可能具有预后良好的腔面亚型。印度人群中的男性乳腺癌目前呈上升趋势。提高患者的认知度、临床医生的高度怀疑指数以及准确的诊断技术有助于在疾病早期进行检测，最终实现更长的总生存期和无病生存期。
