Chikaraddi S B, Krishnappa R, Deshmane V
Department of surgical oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
Indian J Cancer. 2012 Jul-Sep;49(3):272-6. doi: 10.4103/0019-509X.104484.
Cancer of the male breast accounts for about 1% of all malignancies in men and 1% of all breast cancers. Poor level of awareness often results in late presentation and delayed diagnosis in our environment. This study was done to analyse the demographic data, management and survival of male breast cancers in Indian subset of patients and compare it with that of western literature.
A 10 year (2001-2010) retrospective study of all male breast cancers was done. Data regarding the incidence, presentation, histopathology, stage and grade of tumor, management and outcome of patients were analysed.
26 cases of male breast cancer were encountered. This comprised 0.4% of all breast cancers seen in our department during the 10 year period. The ages of patients ranged from 45-75 years with a mean age of 57 years. Family history was present in 4 patients. Clinically, symptoms included self-detected lump in 23 (88.5%) patients, nipple retraction in 12 (46.1%) and pain in 12 (46.1%). All cases were unilateral (16 on right, 10 on left). Disease most commonly involved central quadrant (9 patients). Grade 3 disease was found in 13 patients and Stage 3 disease was most commonly encountered (13 patients). None of our patients received neo adjuvant chemotherapy. 20 (76.9%) patients had modified radical mastectomy and 6 (23.1%) had radical mastectomy. Most of our patients were hormone receptor positive (21 patients). Bilateral orchidectomy, Adjuvant chemotherapy, Adjuvant radiotherapy and Tamoxifen were offered in 3 (11.5%), 16 (61.5%), 17 (65.4%) and 15 (57.7%) patients respectively. Follow up ranged from 1-59 months.
Male breast cancer is rare in our centre. Late presentation with advanced disease is a common feature in our environment. Further multiinstitutional, prospective studies are needed for better understanding of management of male breast cancers in Indian subset of patients.
男性乳腺癌约占男性所有恶性肿瘤的1%，以及所有乳腺癌的1%。在我们所处的环境中，认知水平低下常常导致就诊延迟和诊断延误。本研究旨在分析印度患者亚组中男性乳腺癌的人口统计学数据、治疗情况和生存率，并与西方文献进行比较。
对所有男性乳腺癌患者进行了一项为期10年（2001 - 2010年）的回顾性研究。分析了有关发病率、临床表现、组织病理学、肿瘤分期和分级、治疗情况及患者预后的数据。
共发现26例男性乳腺癌患者。这占我们科室在10年期间所见所有乳腺癌患者的0.4%。患者年龄在45 - 75岁之间，平均年龄为57岁。4例患者有家族史。临床上，症状包括23例（88.5%）患者自我发现肿块、12例（46.1%）乳头回缩和12例（46.1%）疼痛。所有病例均为单侧（右侧16例，左侧10例）。疾病最常累及中央象限（9例患者）。13例患者为3级疾病，最常见的是3期疾病（13例患者）。我们的患者均未接受新辅助化疗。20例（76.9%）患者接受了改良根治性乳房切除术，6例（23.1%）接受了根治性乳房切除术。我们的大多数患者激素受体呈阳性（21例患者）。分别有3例（11.5%）、16例（61.5%）、17例（65.4%）和15例（57.7%）患者接受了双侧睾丸切除术、辅助化疗、辅助放疗和他莫昔芬治疗。随访时间为1 - 59个月。
男性乳腺癌在我们中心较为罕见。在我们所处的环境中，晚期就诊且疾病进展是常见特征。需要进一步开展多机构前瞻性研究，以更好地了解印度患者亚组中男性乳腺癌的治疗情况。
