沙丁胺醇在人体中的药效学。

Pharmacodynamics of salbutamol in humans.

作者信息

Chazan R, Droszcz W, Maruchin J E

机构信息

Department of Pneumonology, Medical School, Warsaw, Poland.

出版信息

Int J Clin Pharmacol Ther Toxicol. 1988 Aug;26(8):385-7.

PMID:3220612

Abstract

Twenty patients with mild chronic bronchial asthma (females and males between 45-69 years old) treated with single dose of 0.5 mg at 1 ml of salbutamol were investigated. Measurements of heart rate, blood pressure, peak expiratory flow rate (PEFR) and plasma concentration or glucose, potassium and non-esterified fatty acids-NEFA, and salbutamol plasma levels were recorded at the same time before and 2, 5, 15, 30, 60, 75, 90, 120, 180, 240, and 360 min after salbutamol injection. Decrease in heart rate, blood systolic pressure and metabolic changes correlated with the salbutamol plasma level. Increase in PEFR was elevated much longer.

摘要

对20例轻度慢性支气管哮喘患者（年龄在45至69岁之间的男性和女性）进行了研究，这些患者接受了单剂量1毫升含0.5毫克沙丁胺醇的治疗。在注射沙丁胺醇前以及注射后2、5、15、30、60、75、90、120、180、240和360分钟同时记录心率、血压、呼气峰值流速（PEFR）以及血浆葡萄糖、钾和非酯化脂肪酸-NEFA的浓度，还有沙丁胺醇的血浆水平。心率、收缩压的下降以及代谢变化与沙丁胺醇血浆水平相关。PEFR的升高持续时间更长。