沙丁胺醇的代谢效应：气雾剂与静脉给药的比较
Metabolic effects of salbutamol: comparison of aerosol and intravenous administration.
作者信息
Neville A, Palmer J B, Gaddie J, May C S, Palmer K N, Murchison L E
出版信息
Br Med J. 1977 Feb 12;1(6058):413-4. doi: 10.1136/bmj.1.6058.413.
Abstract
The effects of intravenous salbutamol (4 mug/kg) were compared with those of aerosol salbutamol (200 mug) in 10 asthmatic patients in a double-blind placebo-controlled study. Both methods of administration produced equal bronchodilatation. Intravenous salbutamol caused significant increases in plasma insulin and glucose levels and a fall in serum potassium concentration in addition to tachycardia and tremor, whereas aerosol salbutamol produced only a small transient increase in the plasma glucose level. The initially raised non-esterified fatty acid levels decreased significantly after aerosol and placebo but not after intravenous salbutamol.
摘要
在一项双盲安慰剂对照研究中，对10名哮喘患者静脉注射沙丁胺醇（4微克/千克）与雾化吸入沙丁胺醇（200微克）的效果进行了比较。两种给药方法产生的支气管扩张效果相同。静脉注射沙丁胺醇除了引起心动过速和震颤外，还导致血浆胰岛素和葡萄糖水平显著升高以及血清钾浓度下降，而雾化吸入沙丁胺醇仅使血浆葡萄糖水平出现小幅短暂升高。雾化吸入和安慰剂治疗后，最初升高的非酯化脂肪酸水平显著下降，但静脉注射沙丁胺醇后未下降。
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