Perlík F, Janku I, Kordac V
1st Department of Medicine, Faculty of Medicine, Charles University, Prague 2, Czechoslovakia.
Int J Clin Pharmacol Ther Toxicol. 1988 Aug;26(8):413-6.
Using a one compartment pharmacokinetic model with constant rate of availability for absorption, the disposition of paracetamol was compared after administration of Paralen (paracetamol 500 mg in one tablet) with data obtained after administration of two composite analgesic preparations: Guajanal (paracetamol 500 mg, guaiphenesin 200 mg) and Ataralgin (paracetamol 500 mg, guaiphenesin 130 mg, caffeine 70 mg). The combination of paracetamol with guaiphenesin significantly increased the rate of paracetamol absorption availability, most probably by accelerating its transfer from the stomach to the small intestine. The combination with guaiphenesin and caffeine slightly reduced the rate of paracetamol absorption availability but the difference was not statistically significant. The relative bioavailability of paracetamol from the composite analgesic preparations, however, did not show a statistically significant difference as compared to the preparation where paracetamol was present as a single component.
使用具有恒定吸收可用性速率的单室药代动力学模型，将Paralen（每片含对乙酰氨基酚500毫克）给药后对乙酰氨基酚的处置情况与两种复合镇痛制剂给药后获得的数据进行比较：Guajanal（对乙酰氨基酚500毫克，愈创甘油醚200毫克）和Ataralgin（对乙酰氨基酚500毫克，愈创甘油醚130毫克，咖啡因70毫克）。对乙酰氨基酚与愈创甘油醚的组合显著提高了对乙酰氨基酚的吸收可用性速率，很可能是通过加速其从胃向小肠的转运。与愈创甘油醚和咖啡因的组合略微降低了对乙酰氨基酚的吸收可用性速率，但差异无统计学意义。然而，与对乙酰氨基酚作为单一成分的制剂相比，复合镇痛制剂中对乙酰氨基酚的相对生物利用度没有显示出统计学上的显著差异。
