Freixa Marta, Úria Sara, da Silva Glória Nunes
Department of Internal Medicine, Hospital Pulido Valente, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.
Eur J Case Rep Intern Med. 2020 Feb 4;7(3):001448. doi: 10.12890/2020_001448. eCollection 2020.
Reactive arthritis (ReA) with the classic triad of arthritis, conjunctivitis and urethritis, previously termed Reiter's syndrome, is a systemic illness, usually induced by genitourinary or gastrointestinal infections. However, it can be a rare complication of intravesical Bacillus Calmette-Guérin instillation (iBCG), a therapy prepared from attenuated strains of , a common and effective treatment for carcinoma in situ of the bladder (CisB). We report a case of a patient with CisB who developed ReA after iBCG. The symptoms resolved completely with corticosteroids. iBCG was stopped with no recurrence of carcinoma within 2 years.
ReA is an aseptic arthritis, usually triggered by genitourinary or gastrointestinal infections, generally in individuals positive for HLA-B27.Septic arthritis and microcrystalline arthritis can mimic ReA and they must be ruled out with arthrocentesis.ReA may be considered as a complication in patients under iBCG.
反应性关节炎（ReA）具有关节炎、结膜炎和尿道炎的经典三联征，以前称为赖特综合征，是一种全身性疾病，通常由泌尿生殖系统或胃肠道感染引起。然而，它可能是膀胱内卡介苗灌注（iBCG）的一种罕见并发症，iBCG是一种由卡介苗减毒株制备的疗法，是膀胱原位癌（CisB）的一种常用且有效的治疗方法。我们报告一例CisB患者在iBCG治疗后发生ReA的病例。症状通过皮质类固醇完全缓解。停用iBCG，2年内癌症未复发。
ReA是一种无菌性关节炎，通常由泌尿生殖系统或胃肠道感染引发，一般发生在HLA - B27阳性个体中。化脓性关节炎和微晶性关节炎可模仿ReA，必须通过关节穿刺术排除。iBCG治疗的患者中，ReA可被视为一种并发症。
