Tymms D J, Tooke J E
Department of Medicine, General Infirmary, Leeds, United Kingdom.
Int J Microcirc Clin Exp. 1988 Nov;7(4):347-56.
The effects of strict blood glucose control on total skin blood flow and capillary blood flow velocity in finger nailfold capillaries were assessed in nine diabetics. Measurements were made before (blood glucose: 11.2 +/- 0.8 mmol/l) and after nine days of continuous subcutaneous insulin infusion (CSII) (blood glucose 6.2 +/- 0.8 mmol/l, p less than 0.001). Resting finger skin blood flow, measured by venous occlusion plethysmography, was 18.6 +/- 2.7 ml/100 ml tissue/min before and 12.6 +/- 2.7 ml/100 ml/min (ns) after CSII. Nailfold capillary red cell velocity, measured by television video microscopy, rose significantly from 0.36 +/- 0.09 mm/s before to 0.71 +/- 0.14 mm/s (p less than 0.01) after CSII. Venous oxygen tension, measured in samples of blood taken from an antecubital vein, tended to fall after CSII (from 6.1 +/- 0.4 kPa to 4.6 +/- 0.5 kPa/ns). No change was seen in whole blood viscosity, plasma viscosity or red cell filtration rate during the study although heart rate fell from 81.3 +/- 2.0 to 75.2 +/- 1.7 beats/min (p less than 0.02). The results suggest that there is a redistribution of skin blood flow following improved diabetic control which favours the nutritive microcirculation.
对9名糖尿病患者评估了严格血糖控制对总皮肤血流量和指甲襞毛细血管内毛细血管血流速度的影响。在连续皮下胰岛素输注（CSII）9天之前（血糖：11.2±0.8 mmol/L）和之后（血糖6.2±0.8 mmol/L，p<0.001）进行测量。通过静脉阻断体积描记法测量的静息手指皮肤血流量，在CSII之前为18.6±2.7 ml/100 ml组织/分钟，之后为12.6±2.7 ml/100 ml/分钟（无显著差异）。通过电视视频显微镜测量的指甲襞毛细血管红细胞速度，在CSII后从之前的0.36±0.09 mm/s显著升至0.71±0.14 mm/s（p<0.01）。从肘前静脉采集的血样中测量的静脉血氧张力在CSII后有下降趋势（从6.1±0.4 kPa降至4.6±0.5 kPa/无显著差异）。在研究期间，全血粘度、血浆粘度或红细胞滤过率未见变化，尽管心率从81.3±2.0降至75.2±1.7次/分钟（p<0.02）。结果表明，糖尿病控制改善后皮肤血流会重新分布，有利于营养性微循环。
