Department of Chemistry, Synthetic Organic Chemistry Laboratory, MLSU, Udaipur, 313001, India.
Department of Pharmacy, B. N. University, MLSU, Udaipur, 313001, India.
Top Curr Chem (Cham). 2020 Mar 23;378(2):34. doi: 10.1007/s41061-020-0298-4.
In past decades, interdisciplinary research has been of great interest for scholars. Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. The presence of sulfur enhances their pharmacological properties, and, therefore, they are used as vehicles in the synthesis of valuable organic combinations. They show varied biological properties viz. anticancer, anticonvulsant, antimicrobial, anti-inflammatory, neuroprotective, antioxidant activity and so on. This diversity in the biological response makes it a highly prized moiety. Based on literature studies, various synthetic approaches like multicomponent reaction, click reaction, nano-catalysis and green chemistry have been employed to improve their selectivity, purity, product yield and pharmacokinetic activity. In this review article, we have summarized systematic approaches for the synthesis of thiazolidine and its derivatives, along with their pharmacological activity, including advantages of green synthesis, atom economy, cleaner reaction profile and catalyst recovery which will help scientists to probe and stimulate the study of these scaffolds.
在过去的几十年中，跨学科研究一直是学者们非常感兴趣的领域。噻唑烷类化合物作为有机合成和药物化学之间的桥梁，促使研究人员探索新的药物候选物。噻唑烷类化合物是非常有趣的五元杂环，存在于多种天然和生物活性化合物中，其特点是硫原子位于第一位，氮原子位于第三位。硫原子的存在增强了它们的药理特性，因此它们被用作合成有价值的有机化合物的载体。它们表现出多种生物活性，如抗癌、抗惊厥、抗菌、抗炎、神经保护、抗氧化活性等。这种生物反应的多样性使它成为一个非常有价值的部分。基于文献研究，已经采用了多种合成方法，如多组分反应、点击反应、纳米催化和绿色化学，以提高它们的选择性、纯度、产率和药代动力学活性。在这篇综述文章中，我们总结了噻唑烷及其衍生物的系统合成方法及其药理学活性，包括绿色合成、原子经济性、更清洁的反应谱和催化剂回收的优点，这将有助于科学家探索和激发对这些支架的研究。
