Dhadda Surbhi, Sharma Shaily, Jakhar Prakash, Sharma Himanshu
Department of Chemistry, Faculty of Basic and Applied Sciences, Vivekananda Global University Jagatpura Jaipur Rajasthan 303012 India.
Microwave Chemistry Lab, Department of Chemistry, UCOS, Mohanlal Sukhadia University Udaipur Rajasthan 313001 India
RSC Adv. 2023 Jan 25;13(6):3723-3742. doi: 10.1039/d2ra07474e. eCollection 2023 Jan 24.
The development of new strategies for the production of nitrogen and sulfur-containing heterocycles remains an extremely alluring but challenging proposition. Among these heterocyclic compounds, spiro-thiazolidines are a distinct class of heterocyclic motifs with an all-encompassing range of pharmaceutical activities such as anti-histaminic, anti-proliferative, anesthetic, hypnotic, anti-fungal, anti-inflammatory, anti-HIV, anthelmintic, CNS stimulant, and anti-viral potentials. Consequently, investigators have produced these heterocycles through diversified intricate pathways as object structures for medicinal studies. Notwithstanding their innumerable manmade solicitations, there is yet no special periodical on MCRs concerning spiro-thiazolidine green synthesis. Thus, this in-depth review encompasses the excursion of MCRs to spiro-thiazolidines, including the environment-friendly synthetic approaches, reaction situations, rationale behind the optimal selection of catalyst, scope, anticipated mechanism, and biological activities. In this review, we have focussed on the furthermost current developments in spiro-thiazolidine creation under different conditions, such as ionic liquid-assisted, microwave-assisted, on-water, solid-supported acid-catalyzed, asymmetric, and nanocatalyst-assisted syntheses, developed over the last 8 years. This study details works regarding the total amalgamation of spiro-thiazolidines under and -containing heterocycles. Furthermore, this article summarizes the developments of artificially and pharmaceutically important spiro-thiazolidine candidates.
开发含氮和含硫杂环化合物的新策略仍然是一个极具吸引力但又充满挑战的命题。在这些杂环化合物中，螺噻唑烷是一类独特的杂环结构，具有广泛的药物活性，如抗组胺、抗增殖、麻醉、催眠、抗真菌、抗炎、抗艾滋病毒、驱虫、中枢神经系统刺激和抗病毒潜力。因此，研究人员通过多种复杂途径合成了这些杂环化合物，作为药物研究的目标结构。尽管它们有无数的人工合成需求，但目前还没有专门关于多组分反应（MCRs）用于螺噻唑烷绿色合成的期刊。因此，这篇深入的综述涵盖了多组分反应在合成螺噻唑烷方面的进展，包括环境友好的合成方法、反应条件、催化剂最佳选择背后的原理、范围、预期机制和生物活性。在这篇综述中，我们重点关注了过去8年中在不同条件下螺噻唑烷合成的最新进展，如离子液体辅助、微波辅助、水相、固载酸催化、不对称和纳米催化剂辅助合成。这项研究详细介绍了有关螺噻唑烷与含氮和含硫杂环化合物的完全融合的工作。此外，本文总结了人工合成和具有药学重要性的螺噻唑烷候选物的进展。
