可见光促进吲哚-炔酮的硒叶立德环化反应，构建 3-硒代螺吲哚啉类抗癌药物。
Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents.
机构信息
Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, 541004, People's Republic of China, Guilin.
出版信息
Chem Asian J. 2020 May 15;15(10):1536-1539. doi: 10.1002/asia.202000298. Epub 2020 Apr 7.
A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.
发展了一种在室温、空气氛围下、无需金属、可见光诱导吲哚-炔酮与二硒醚的高效螺环化反应，以中等至良好产率制备 3-硒螺吲哚啉的方法。通过 MTT 法测试了所得产物的体外抗癌活性，化合物 3c 和 3e 表现出很强的癌细胞生长抑制活性。
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