Institut des Sciences Moléculaires, UMR 5255, CNRS, Université de Bordeaux, 351 Cours de la libération, 33405 Talence, France.
Org Lett. 2020 Apr 3;22(7):2838-2843. doi: 10.1021/acs.orglett.0c00908. Epub 2020 Mar 24.
A simple procedure has been optimized for the preparation of alkenylaminoborane from alkynes using diisopropylaminoborane and HZrCpCl. Coupled with a magnesium-catalyzed dehydrogenation, it allowed for the use of air- and moisture-stable diisopropylamine. This synthesis has been extended to a one-pot sequence leading directly to bromoalkenes with controlled stereochemistry. As such, it provides an easy, scalable, cheap process to access alkenylboronates and both ()- and ()-bromoalkenes from commercially available alkynes.
已经优化了一种简单的方法，用于使用二异丙基氨基硼烷和 HZrCpCl 从炔烃制备烯基氨基硼烷。与镁催化脱氢相结合，它允许使用空气稳定和防潮的二异丙胺。该合成已扩展到一锅序列，直接得到具有控制立体化学的溴代烯烃。因此，它提供了一种简单、可扩展、廉价的方法，可从商业上可获得的炔烃获得烯基硼酸酯和 ()-和 ()-溴代烯烃。
