Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
Chem Commun (Camb). 2020 Apr 23;56(33):4587-4590. doi: 10.1039/d0cc01576h.
The oxidative coupling of secondary aldehydes and sulfinate salts is achieved using copper catalysis to form α-sulfonyl aldehydes. The use of an acidic co-solvent is important to adjust the oxidation potential of MnO2 as an oxidant. A broad range of sulfonylated aldehydes is prepared, and their further functionalisation is demonstrated. A dual ionic/radical pathway mechanism is proposed.
使用铜催化实现了二级醛和亚磺酸盐盐的氧化偶联，生成α-磺酰基醛。使用酸性共溶剂对于调节 MnO2 作为氧化剂的氧化电位非常重要。制备了广泛的磺酰化醛，并证明了它们的进一步官能化。提出了一种双离子/自由基途径机制。
