Breuninger H, Langer B, Rassner G
Abteilung Dermatologie I, Universitäts-Hautklinik Tübingen.
Hautarzt. 1988 Jul;39(7):430-4.
Using the TNM classification established by the UICC, 427 squamous cell carcinomas of the skin and lower lip were classified as belonging to the T class. Additional histometric, histologic, and clinical tumor parameters were also recorded. Prognostic relevance was checked by comparing the overall data with those for metastatic tumors. The results showed that the overall metastasis rate was low (carcinoma of skin: 3.5%; carcinoma of lower lip: 2.7%; mean follow-up period: 5 years). Moreover, the prognoses based on the tumor diameter classes in the TNM system were not specific. Earlier findings tend to indicate that tumor thickness, depth of infiltration, and grade of malignancy should also be taken into consideration if the prognosis is to be estimated accurately. If the level and tumor thickness are taken into consideration, a large group of tumors (50%) can be separated: these tumors do not metastasize, even though they are at least 2 mm thick, and they do not infiltrate the subcutaneous tissue (no risk group).
采用国际抗癌联盟（UICC）制定的TNM分类法，将427例皮肤和下唇鳞状细胞癌归入T类。还记录了其他组织测量学、组织学和临床肿瘤参数。通过将总体数据与转移性肿瘤的数据进行比较，检查其预后相关性。结果显示，总体转移率较低（皮肤癌：3.5%；下唇癌：2.7%；平均随访期：5年）。此外，TNM系统中基于肿瘤直径分类的预后并不具有特异性。早期研究结果倾向于表明，如果要准确估计预后，还应考虑肿瘤厚度、浸润深度和恶性程度。如果考虑分期和肿瘤厚度，可以区分出一大组肿瘤（50%）：这些肿瘤即使至少2毫米厚也不会转移，并且不会浸润皮下组织（无风险组）。
