Pătraşcu V, Georgescu Claudia Valentina, Tănase Loredana, Mogoantă L
Department of Dermatology, University of Medicine and Pharmacy of Craiova.
Rom J Morphol Embryol. 2006;47(2):147-53.
The squamous cell carcinoma of the lip has a metastasizing potential by lymphatic or/and sanguine ways.
Knowing the profile of the squamous cell carcinoma of the lip with a high degree of metastasizing.
We have analyzed on a group of 322 patients the influence of the degree of the histological differentiation of the tumor and the influence of the seriousness of the invasion over the metastasized potential. The bioptic fragments have been processed according to the usual histological technique paraffin embedding, and the sections have been colored with Hematoxylin-Eosin. Some of the cases have been immunomarked, to confirm the diagnosis, with antibody anti-cytokeratins, anti-vimentin, anti-protein S100 and anti-alpha actin.
12.24% of the patients with tumors with Broders II degree, 28.5% of those with Broders III degree and 52.94% of those patients with Broders IV degree presented metastasis, that show that the incidence of the regional ganglionary metastasis is higher in the case of the tumors with a low histological differentiation (test chi(2), p<0.001). 1.88% of the patients with an invasive squamous cell carcinoma under 6 mm and 38.60% of those with tumors of over 6 mm presented metastasis, that show that the risk of metastasizing is higher when the profoundness of the invasion is over 6 mm (test chi(2), p<0.001). In two cases we faced the changing of the malignity degree, meaning that it got worse passing from the Broders III degree (primary tumor) to Broders IV degree (relapse of the tumor).
The histological differential degree of the tumor and the profoundness of the invasion are two important parameters when shaping the profile of the squamous cell carcinoma of the lip with a high degree of metastasis. The degree of malignity of the tumor may worsen during the evolution of the lip cancer, raising the risk of metastasizing as well.
唇部鳞状细胞癌具有通过淋巴或/和血行途径转移的潜能。
了解具有高度转移潜能的唇部鳞状细胞癌的特征。
我们分析了一组322例患者中肿瘤组织学分化程度以及侵袭严重程度对转移潜能的影响。活检组织块按照常规组织学技术进行石蜡包埋处理，切片用苏木精-伊红染色。部分病例用抗细胞角蛋白、抗波形蛋白、抗S100蛋白和抗α肌动蛋白抗体进行免疫标记以确诊。
Broders II级肿瘤患者中有12.24%出现转移，Broders III级患者中有28.5%出现转移，Broders IV级患者中有52.94%出现转移，这表明组织学分化程度低的肿瘤区域淋巴结转移发生率更高（卡方检验，p<0.001）。侵袭深度小于6mm的浸润性鳞状细胞癌患者中有1.88%出现转移，而肿瘤大于6mm的患者中有38.60%出现转移，这表明侵袭深度超过6mm时转移风险更高（卡方检验，p<0.001）。有两例出现恶性程度改变，即从Broders III级（原发肿瘤）转变为Broders IV级（肿瘤复发）时病情恶化。
肿瘤的组织学分化程度和侵袭深度是塑造具有高度转移潜能的唇部鳞状细胞癌特征的两个重要参数。在唇癌发展过程中肿瘤恶性程度可能会恶化，转移风险也会增加。
