Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Can J Physiol Pharmacol. 2020 Apr;98(4):228-235. doi: 10.1139/cjpp-2019-0537. Epub 2020 Mar 24.
To test if magnitudes of the beneficial actions of CO water bath therapy on blood flow and vascular density are dependent upon temperature, ischemia in the hind limb of rats was induced by occluding the left femoral artery for 2 weeks and the animals were exposed to water bath therapy with or without CO at 34 or 41 °C for 4 weeks (20 min treatment each day for 5 days/week). CO water bath therapy at 34 °C increased peak, minimal, and mean blood flow by 190%-600% in the ischemic limb. On the other hand, CO water bath treatment at 41 °C increased these parameters of blood flow by 37%, 55%, and 41%, respectively, in the ischemic limb. The small blood vessel count, an index of vascular density, in the ischemic limb was increased by CO water bath therapy at 34 and 41 °C by 32% and 122%, respectively. No changes in the ischemic animals by CO water bath therapy at 34 or 41 °C were observed in the heart rate, R-R interval, and plasma lipid or glucose levels. These data indicate that the beneficial effect of CO water bath therapy at 34 °C on blood flow in the ischemic muscle is greater whereas that on vascular density is smaller than changes in these parameters at 41 °C.
为了测试 CO 水浴疗法对血流和血管密度的有益作用的幅度是否取决于温度，通过阻塞左股动脉使大鼠后肢缺血 2 周，并将动物暴露于 CO 水浴治疗中，温度分别为 34°C 或 41°C，持续 4 周（每周 5 天，每天治疗 20 分钟）。CO 水浴治疗 34°C 可使缺血肢体的峰值、最小和平均血流增加 190%至 600%。另一方面，CO 水浴治疗 41°C 可使缺血肢体的这些血流参数分别增加 37%、55%和 41%。CO 水浴治疗 34°C 和 41°C 均可使缺血肢体中小血管计数（血管密度的指标）增加 32%和 122%。在 34°C 或 41°C 的 CO 水浴治疗中，在缺血动物中未观察到心率、R-R 间隔以及血浆脂质或葡萄糖水平的变化。这些数据表明，CO 水浴治疗 34°C 对缺血肌肉血流的有益作用大于 41°C，而对血管密度的作用则小于这些参数的变化。
