Marchenkova L A, Makarova E V, Vasilieva V A, Eryomushkin M A, Styazhkina E M, Razvalyayeva D V, Chesnikova E I, Gerasimenko M Yu
National Medical Research Center for Rehabilitation and Balneology, Moscow, Russia.
Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
Vopr Kurortol Fizioter Lech Fiz Kult. 2020;97(1):25-34. doi: 10.17116/kurort20209701125.
Study of the effect of taking a complex biologically active food supplement with calcium and vitamins D and B to the effectiveness and duration of medical rehabilitation effect at patients with osteoporosis and with a high risk of fractures.
We examined 119 men and women with osteoporosis and (or) with a high risk of fractures, beginning a course of medical rehabilitation. The 1st study group (SG1) included 41 patients who had already received antiresorptive therapy. In SG2 and SG3, 39 patients who did not receive pathogenetic therapy of osteoporosis were included by the randomization method. For patients SG1 and SG2, a complex biologically active food supplement Osteomed forte was prescribed to use within 12 months. The dynamics of tensodynamometry, stabilometry and functional tests were evaluated in 20 days, 6 and 12 months after the start of the study.
The muscle strength indicators achieved during the 20-day training session compared to the initial level were maintained for 12 months in extensor and flexor of the back at patients within SG1 and SG2, as well as up to 6 months in the lateral flexor of the back at patients of SG1. At patients within SG3, the effect of medical rehabilitation completely regressed after 6 months. Higher stabilization parameters after 6 and 12 months in comparison with the initial level were observed only in patients within SG1 and SG2. The effect achieved during rehabilitation was supported for 12 months in the 'stand on one leg' test within SG1, comparing in contrast to SG3, where a deterioration in the average value of the test indicator was noted.
Long-term use of food supplements containing calcium salts with vitamins D and Bcan be recommended to maintain the effect of rehabilitation measures at patients with osteoporosis and with a high risk of fractures, more preferably in combination with antiresorptive therapy.
研究服用含钙及维生素D和B的复合生物活性食品补充剂对骨质疏松症及骨折高风险患者医学康复效果的有效性和持续时间的影响。
我们检查了119名患有骨质疏松症和（或）骨折高风险且开始医学康复疗程的男性和女性。第一研究组（SG1）包括41名已接受抗吸收治疗的患者。通过随机化方法，SG2和SG3纳入了39名未接受骨质疏松症病因治疗的患者。对于SG1和SG2的患者，开具了复合生物活性食品补充剂Osteomed forte，规定在12个月内使用。在研究开始后的20天、6个月和12个月评估张力测定、稳定测定和功能测试的动态变化。
与初始水平相比，SG1和SG2患者背部伸肌和屈肌在20天训练期间达到的肌肉力量指标在之后12个月保持稳定，SG1患者背部侧屈肌的该指标在6个月内保持稳定。在SG3患者中，医学康复效果在6个月后完全消退。仅在SG1和SG2患者中观察到6个月和12个月后与初始水平相比有更高的稳定参数。与SG3相比，SG1患者在“单腿站立”测试中康复期间取得的效果在12个月内得到维持，而SG3测试指标的平均值出现恶化。
对于骨质疏松症及骨折高风险患者，可推荐长期使用含维生素D和B的钙盐食品补充剂以维持康复措施的效果，更优选与抗吸收治疗联合使用。
