Boonen S, Vanderschueren D, Haentjens P, Lips P
Leuven University Center for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Belgium.
J Intern Med. 2006 Jun;259(6):539-52. doi: 10.1111/j.1365-2796.2006.01655.x.
Combined calcium and vitamin D supplementation is an essential component of the management of osteoporosis, supported by a strong scientific rationale. The types of individuals who should receive calcium and vitamin D supplements are those: (i) patients with documented osteoporosis receiving antiresorptive or anabolic treatment; (ii) patients receiving glucocorticoids; and (iii) individuals with or at high risk of calcium and/or vitamin D insufficiencies, in particular older women and men. This article describes the evidence base that supports targeting these groups. Benefits are most apparent when 800 IU day(-1) vitamin D is complemented with a dose of 1000-1200 mg day(-1) elemental calcium. Compliance is also key to optimizing clinical efficacy.
联合补充钙和维生素D是骨质疏松症管理的重要组成部分，有充分的科学依据支持。应该接受钙和维生素D补充剂的人群包括：（i）确诊骨质疏松症且正在接受抗吸收或促合成治疗的患者；（ii）正在接受糖皮质激素治疗的患者；以及（iii）存在钙和/或维生素D不足或有高风险的个体，特别是老年女性和男性。本文描述了支持针对这些人群的证据基础。当每日补充800 IU维生素D并搭配1000 - 1200 mg元素钙时，益处最为明显。依从性也是优化临床疗效的关键。
