State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
J Mater Chem B. 2020 Apr 21;8(15):3092-3103. doi: 10.1039/c9tb02855b. Epub 2020 Mar 24.
It has been proved that silicon-substituted calcium phosphate ceramics possess superior bone regeneration and resorbability to HA, while the synthesis of single-phase nanocrystallized high Si-containing calcium phosphate is still a challenge. In the present work, a novel and facile aqueous precipitation method assisted with ultrasonic irradiation was adopted firstly to synthesise a single-phase nanocrystallized calcium silicophosphate (Ca(PO)SiO, CPS) biomaterial. Crystallization and morphology of Si-apatite precursors synthesized with or without ultrasonic assistance were primarily investigated and the related mechanism was discussed. Moreover, the sinterability, in vitro bioactivity and osteogenic activity of the synthesized CPS were studied in detail. Results showed that an ultrasonic cavitation effect could be beneficial to form a highly dispersive CPS precursor with a single Si-apatite phase, which greatly reduced the calcination temperature of CPS from 1350 °C to 1000 °C. Nanocrystallized CPS powders were obtained successfully under ultrasound-assisted conditions, which showed superior sinterability, in vitro bioactivity and osteogenic activity than those of micron-sized CPS and HA powders. It might be a promising candidate material for bone tissue regeneration applications.
已经证明，硅取代的磷酸钙陶瓷具有优于 HA 的骨再生和可吸收性，而单相纳米晶高硅含磷酸钙的合成仍然是一个挑战。在本工作中，首次采用了一种新颖且简便的水相沉淀法，辅助超声辐射，来合成单相纳米晶硅磷灰石钙（Ca(PO)SiO，CPS）生物材料。主要研究了有无超声辅助下合成的 Si-磷灰石前体的结晶和形态，并探讨了相关机理。此外，还详细研究了合成的 CPS 的烧结性能、体外生物活性和成骨活性。结果表明，超声空化效应有利于形成具有单一 Si-磷灰石相的高分散 CPS 前体，这大大降低了 CPS 的煅烧温度，从 1350°C 降低到 1000°C。在超声辅助条件下成功获得了纳米晶 CPS 粉末，其烧结性能、体外生物活性和成骨活性均优于微米级 CPS 和 HA 粉末。它可能是一种有前途的骨组织再生应用候选材料。
