Biological Therapy Institute, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Health Science Center, Shenzhen University, Shenzhen 518055, China.
Shenzhen City Futian Qu Rheumatology Specialist Hospital, Shenzhen 518089, China.
Int Immunopharmacol. 2020 Jun;83:106391. doi: 10.1016/j.intimp.2020.106391. Epub 2020 Mar 21.
Interleukin (IL)-37 belongs to the IL-1 cytokine family. It has anti-inflammatory effects on numerous autoimmune diseases such as asthma, psoriasis, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), multiple sclerosis (MS) and rheumatoid arthritis (RA). Mechanistically, IL-37 plays an anti-inflammatory role by regulating the expression of inflammatory factors in two ways: binding extracellular receptors IL-18R or transferring into the nucleus with Smad3. IBD is a kind of idiopathic intestinal inflammatory disease with unknown etiology and pathogenesis. Recent researches had proved that IL-37 is negatively involved in the pathogenesis and development of IBD. Among various inflammatory diseases, IL-37 has been shown to regulate inflammatory development by acting on various immune cells such as neutrophils, macrophages (Mϕ), dendritic cells (DCs), T cells and intestinal epithelial cells. This review summarizes the biological role of IL-37, and its immunoregulatory effects on the immune cells, especially anti-inflammatory function in both human and experimental models of IBD.
白细胞介素 (IL)-37 属于白细胞介素 1 细胞因子家族。它对许多自身免疫性疾病具有抗炎作用，如哮喘、银屑病、炎症性肠病 (IBD)、系统性红斑狼疮 (SLE)、多发性硬化症 (MS) 和类风湿关节炎 (RA)。从机制上讲，IL-37 通过两种方式调节炎症因子的表达发挥抗炎作用：与细胞外受体 IL-18R 结合或与 Smad3 一起转位入核。IBD 是一种病因和发病机制不明的特发性肠道炎症性疾病。最近的研究证明，IL-37 参与了 IBD 的发病和发展。在各种炎症性疾病中，IL-37 通过作用于中性粒细胞、巨噬细胞 (Mϕ)、树突状细胞 (DC)、T 细胞和肠上皮细胞等各种免疫细胞来调节炎症的发展。本综述总结了 IL-37 的生物学作用及其对免疫细胞的免疫调节作用，特别是在人类和实验性 IBD 模型中的抗炎功能。
