Mahdavi Sharif Pouya, Jabbari Parnian, Razi Sepideh, Keshavarz-Fathi Mahsa, Rezaei Nima
Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Cytokine. 2020 Mar 21;130:155066. doi: 10.1016/j.cyto.2020.155066.
TNF-alpha is involved in many physiologic and pathologic cellular pathways, including cellular proliferation, differentiation, and death, regulation of immunologic reactions to different cells and molecules, local and vascular invasion of neoplasms, and destruction of tumor vasculature. It is obvious that because of integrated functions of TNF-alpha inside different physiologic systems, it cannot be used as a single-agent therapy for neoplasms; however, long-term investigation of its different cellular pathways has led to recognition of a variety of subsequent molecules with more specific interactions, and therefore, might be suitable as prognostic and therapeutic factors for neoplasms. Here, we will review different aspects of the TNF-alpha as a cytokine involved in both physiologic functions of cells and pathologic abnormalities, most importantly, cancers.
肿瘤坏死因子-α（TNF-α）参与许多生理和病理细胞途径，包括细胞增殖、分化和死亡，对不同细胞和分子的免疫反应调节，肿瘤的局部和血管侵袭，以及肿瘤血管的破坏。显然，由于TNF-α在不同生理系统中的综合功能，它不能用作肿瘤的单一药物治疗；然而，对其不同细胞途径的长期研究已导致识别出各种具有更特异性相互作用的后续分子，因此，可能适合作为肿瘤的预后和治疗因素。在此，我们将综述TNF-α作为一种细胞因子在细胞生理功能和病理异常（最重要的是癌症）中涉及的不同方面。
