Laron Zvi, Werner Haim
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Petah Tikva, Israel, E-mail:
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Pediatr Endocrinol Rev. 2020 Mar;17(Suppl 1):191-197. doi: 10.17458/per.vol17.2020.lw.insulinghpotentialoncogene.
Both in vitro and in vivo experimental studies proved that insulin has an important anabolic role. This physiological function of insulin is reflected in its well documented involvement in protein metabolism and in acceleration of cell proliferation. Support for a growth promoting action of insulin is further provided by clinical studies that revealed that children with hypoinsulinemia have a decreased growth rate whereas, on the other hand, children with hyperinsulinemia have an accelerated growth. While it was initially assumed that the growth activities of insulin are facilitated via cross-talk with the closely related insulin-like growth factor-1 receptor (IGF-1R), it is now clear that the vast majority of these activities are mediated via direct interaction with the insulin receptor (IR). The present article provides an overview of the growth and proliferative actions of insulin, with an emphasis on a number of pathological conditions, including cancer.
体外和体内实验研究均证明胰岛素具有重要的合成代谢作用。胰岛素的这一生理功能体现在其参与蛋白质代谢以及加速细胞增殖这两个有充分文献记载的方面。临床研究进一步证实了胰岛素的促生长作用，这些研究表明，低胰岛素血症患儿的生长速度减缓，而另一方面，高胰岛素血症患儿的生长速度加快。虽然最初人们认为胰岛素的生长活性是通过与密切相关的胰岛素样生长因子-1受体（IGF-1R）相互作用来实现的，但现在很清楚，这些活性绝大多数是通过与胰岛素受体（IR）的直接相互作用介导的。本文概述了胰岛素的生长和增殖作用，重点关注包括癌症在内的一些病理状况。
