Topolska Kinga, Radzki Radosław Piotr, Filipiak-Florkiewicz Agnieszka, Bieńko Marek, Florkiewicz Adam, Cieślik Ewa
Department of Nutrition Technology and Consumption, Faculty of Food Technology, University of Agriculture, Kraków, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.
Ann Agric Environ Med. 2020 Mar 17;27(1):19-28. doi: 10.26444/aaem/108656. Epub 2019 Apr 25.
Osteoporosis, a disease associated with ovarian hormone deficiency following menopause, is the most common cause of age-related bone loss. Although an optimal intake of Ca is vital - both bone accretion during growth and maintenance in adult life - a great percentage of the population consumes far below the recommended amounts of this mineral. On the other hand, there are evidences that fructans enhance not only Ca absorption, but bone calcium as well.
In the knowledge that estrogen deficiency and insufficient Ca in the diet during postmenopause cause serious problems with resultant osteoporosis, the aim of this study is to assess the effects of a diet enriched in fructan-containing sources alone, or in the "strawberry matrix", on the structure of bone in OVX rats under calcium hypoalimentation.
Experimental animals were female Wistar rats, sham-operated or ovariectomized. The treatment with Ca-restricted diets also contained one of the sources of fructan (Jerusalem artichoke, yacon, Beneo Orafti Synergy1), in the amount providing 8% of fructans. Femur architecture of rats was assessed by tomography and Ca content by the AAS method.
Ovariectomy led to a significant decrease in femoral Ca content, total mineral content and bone density of rats. This study shows that a diet containing inulin-type fructan (especially as a component of strawberry product) improved bone quality (i.e. increase in Ca content in femur, total density in middle part of bone, as well as decrease of endosteal circumference) in OVX rats under calcium hypoalimentation.
These findings suggest that a fructan-enriched diet could be potentially useful for postmenopausal osteoporosis. It is important to determine an optimal dietary level of fructan with the long-term goal of developing a dietary strategy in osteoporosis prevention.
骨质疏松症是一种与绝经后卵巢激素缺乏相关的疾病，是年龄相关性骨质流失的最常见原因。尽管钙的最佳摄入量至关重要——无论是在生长期间的骨质积累还是在成年期的维持——但很大一部分人群的钙摄入量远远低于推荐量。另一方面，有证据表明果聚糖不仅能促进钙的吸收，还能增加骨钙含量。
鉴于绝经后雌激素缺乏和饮食中钙不足会导致严重问题并引发骨质疏松症，本研究的目的是评估单独富含含果聚糖来源的饮食或“草莓基质”饮食对低钙饮食的去卵巢大鼠骨骼结构的影响。
实验动物为雌性Wistar大鼠，进行假手术或卵巢切除术。限制钙饮食的处理还包含一种果聚糖来源（菊芋、雪莲果、比奥奈奥rafti Synergy1），其含量提供8%的果聚糖。通过断层扫描评估大鼠的股骨结构，并通过原子吸收光谱法测定钙含量。
卵巢切除术导致大鼠股骨钙含量、总矿物质含量和骨密度显著降低。本研究表明，在低钙饮食的去卵巢大鼠中，含有菊粉型果聚糖的饮食（特别是作为草莓产品的成分）改善了骨骼质量（即股骨钙含量增加、骨中部总密度增加以及骨内膜周长减小）。
这些发现表明，富含果聚糖的饮食可能对绝经后骨质疏松症有潜在益处。确定果聚糖的最佳饮食水平对于制定预防骨质疏松症的饮食策略这一长期目标很重要。
