身高可独立于体重指数、腰围、腰高比和代谢综合征预测中国天津一般成年人群中非酒精性脂肪性肝病的发生。
Height predict incident non-alcoholic fatty liver disease among general adult population in Tianjin, China, independent of body mass index, waist circumference, waist-to-height ratio, and metabolic syndrome.
机构信息
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
Health Management Center, Tianjin Medical University General Hospital, Tianjin, China.
出版信息
BMC Public Health. 2020 Mar 24;20(1):388. doi: 10.1186/s12889-020-08475-1.
BACKGROUND
Early-life hormonal and nutritional factors can greatly influence the risk of non-alcoholic fatty liver disease (NAFLD). Adult height is a simple marker for these factors. This study aimed to investigate the association between adult height and NAFLD.
METHODS
We performed a prospective cohort study of 35,994 participants aged 25 years or over with measured height at baseline. NAFLD was diagnosed by abdominal ultrasound and self-reported history of alcohol intake. Multivariable Cox proportional hazards regression models were conducted to assess the gender-specific association between height and the risk of NAFLD.
RESULTS
During a follow-up period of 5.5 years, 6245 of 35,994 subjects developed NAFLD. The adjusted hazard ratios (95% confidence interval) of NAFLD for increasing quintiles of height were 1.00 (reference), 0.82 (0.73, 0.92), 0.84 (0.73, 0.97), 0.72 (0.61, 0.85) and 0.63 (0.50, 0.79) (P for trend < 0.0001) in males, and 1.00 (reference), 1.00 (reference), 0.80 (0.69, 0.91), 0.72 (0.61, 0.85), 0.60 (0.49, 0.74) and 0.45 (0.35, 0.59) (P for trend < 0.0001) in females, respectively.
CONCLUSIONS
A higher adult height was associated with lower risk of NAFLD among males and females in Tianjin, China.
背景
生命早期的激素和营养因素会极大地影响非酒精性脂肪性肝病（NAFLD）的风险。成人身高是这些因素的简单标志物。本研究旨在探讨成人身高与 NAFLD 的关系。
方法
我们对 35994 名年龄在 25 岁及以上且基线时身高可测的参与者进行了前瞻性队列研究。通过腹部超声和自我报告的饮酒史诊断 NAFLD。采用多变量 Cox 比例风险回归模型评估身高与 NAFLD 风险之间的性别特异性关联。
结果
在 5.5 年的随访期间，35994 名受试者中有 6245 名发生了 NAFLD。身高五分位递增的 NAFLD 调整后风险比（95%置信区间）为 1.00（参考）、0.82（0.73，0.92）、0.84（0.73，0.97）、0.72（0.61，0.85）和 0.63（0.50，0.79）（趋势 P<0.0001），在男性中，1.00（参考）、1.00（参考）、0.80（0.69，0.91）、0.72（0.61，0.85）、0.60（0.49，0.74）和 0.45（0.35，0.59）（趋势 P<0.0001），在女性中。
结论
在中国天津，成人身高较高与男性和女性的 NAFLD 风险降低相关。
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