Loosen Sven H, Krieg Sarah, Krieg Andreas, Luedde Tom, Kostev Karel, Roderburg Christoph
Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty of Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany.
Epidemiology, IQVIA, 60549 Frankfurt, Germany.
J Clin Med. 2023 Mar 12;12(6):2199. doi: 10.3390/jcm12062199.
Diabetes mellitus is a major global health burden associated with high morbidity and mortality. Although a short adult body height has been associated with increased risk of type 2 diabetes (T2D), there are large inconsistencies between the studies. Therefore, we aimed to investigate the association between body height and T2D in a large cohort of adult outpatients in Germany.
A total of 783,029 adult outpatients with available body height data from the Disease Analyzer (IQVIA) database were included in Germany between 2010 and 2020. The incidence of diabetes mellitus (type 1 and type 2) was evaluated as a function of the patients' body height stratified by age, sex, and body-mass-index (BMI).
In both women and men in all age groups, incidence of T2D decreased with the increasing body height (<50, 51-60, 61-70, and >70 years). There was no association between the body height and the individual HbA1c value. In multivariable Cox regression analyses adjusted for patient age and BMI, hazard ratios for the development of T2D were 1.15 (95% CI: 1.13-1.17) for each 10 cm decrease in body height in women and 1.10 (95% CI: 1.09-1.12) in men. No significant association was found between body height and the development of T1D.
We present the first data from a large cohort of outpatients in Germany, providing strong evidence for an association between adult body height and T2D. These data add to the current literature and might help in implementing body height into existing diabetes risk stratification tools to further reduce morbidity and mortality worldwide.
糖尿病是一种主要的全球健康负担，与高发病率和死亡率相关。尽管成人身材矮小与2型糖尿病（T2D）风险增加有关，但研究之间存在很大差异。因此，我们旨在调查德国一大群成年门诊患者中身高与T2D之间的关联。
2010年至2020年期间，德国共有783,029名成年门诊患者纳入研究，这些患者来自疾病分析器（IQVIA）数据库，有可用的身高数据。将糖尿病（1型和2型）发病率评估为患者身高的函数，并按年龄、性别和体重指数（BMI）进行分层。
在所有年龄组的女性和男性中，T2D发病率均随着身高增加而降低（<50岁、51 - 60岁、61 - 70岁和>70岁）。身高与个体糖化血红蛋白（HbA1c）值之间无关联。在针对患者年龄和BMI进行调整的多变量Cox回归分析中，女性身高每降低10 cm，T2D发病的风险比为1.15（95%CI：1.13 - 1.17），男性为1.10（9%CI：1.09 - 1.12）。未发现身高与1型糖尿病（T1D）发病之间存在显著关联。
我们展示了来自德国一大群门诊患者的首批数据，为成人身高与T2D之间的关联提供了有力证据。这些数据丰富了现有文献，可能有助于将身高纳入现有的糖尿病风险分层工具，以进一步降低全球的发病率和死亡率。
