Weiss Y, Loria Y, Lavene D, Georges D, Safar M, Milliez P
Nouv Presse Med. 1977 Mar 19;6(11):927-30.
A correlation study between the antihypertensive effect and the plasma level of pindolol was performed in 10 patients with permanent essential hypertension. Pindolol was given orally (20 mg/day) during 9 days. The highly significant fall in blood pressure (delta SBP and delta DBP) is directly correlated negatively correlated, to the pretreatment pressure (p less than 0.02 for deltaSBP and p less than 0.05 deltaDBP) and negatively correlated to the pindolol plasma level (P less than 0.001 for delta SBP and p less than 0.05 for delta DBP). Multiple regression analysis shows, for delta SBP, a stronger influence of plasma level than of basal blood pressure. These results suggest that pindolol could have a specific effect in some hypertensive patients.
对10例持续性原发性高血压患者进行了心得静降压效果与血浆水平的相关性研究。在9天内口服心得静（20毫克/天）。血压的显著下降（收缩压和舒张压变化值）与治疗前血压呈负相关（收缩压变化值p<0.02，舒张压变化值p<0.05），与心得静血浆水平也呈负相关（收缩压变化值P<0.001，舒张压变化值p<0.05）。多元回归分析显示，对于收缩压变化值，血浆水平的影响比基础血压更强。这些结果表明，心得静可能对某些高血压患者有特定作用。
