Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Biochem Biophys Res Commun. 2020 May 28;526(2):306-313. doi: 10.1016/j.bbrc.2020.03.084. Epub 2020 Mar 21.
CircRNA is a kind of covalent head-to-tail looped RNA and plays an important role in tumor development. However, the identification of new potential targetable circRNAs to inhibit cancer development is still a huge challenge. In this study, we found that circEHMT1 inhibited migration and invasion of breast cancer cells. Mechanistically, we identified miR-1233-3p as a target of circEHMT1, and the circEHMT1/miR-1233-3p axis regulated matrix metalloprotease 2 (MMP2) by modulating the transcription factor Krϋppel-like factor 4 (KLF4). In summary, we showed that circEHMT1 has potential as a prognostic factor in breast cancer and played a tumor suppressor role via the circEHMT1/miR-1233-3p/KLF4/MMP2 axis.
环状 RNA 是一种共价头尾环状 RNA，在肿瘤发展中发挥重要作用。然而，鉴定新的潜在可靶向环状 RNA 以抑制癌症发展仍然是一个巨大的挑战。在这项研究中，我们发现环状 EHMT1 抑制乳腺癌细胞的迁移和侵袭。在机制上，我们确定 miR-1233-3p 是环状 EHMT1 的靶标，并且环状 EHMT1/miR-1233-3p 轴通过调节转录因子 Krüppel 样因子 4 (KLF4) 来调节基质金属蛋白酶 2 (MMP2)。总之，我们表明环状 EHMT1 可作为乳腺癌的预后因子，并通过环状 EHMT1/miR-1233-3p/KLF4/MMP2 轴发挥肿瘤抑制作用。
