Frazzi Raffaele, Farnetti Enrico, Nicoli Davide
Molecular Pathology Laboratory, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Noncoding RNA. 2025 Jul 29;11(4):56. doi: 10.3390/ncrna11040056.
: Krüppel-like factor 4 () emerged as an epigenetically regulated gene in a variety of settings, including cell reprogramming and malignant cell proliferation. The aim of the present manuscript is to explore the relationship described in recent years between circular RNAs, miRNAs, and . These have been shown to be involved in cancers having diverse histological origins, including some of the most prevalent and deadly tumors for the human population. Expression and protein levels of this transcription factor correlate with invasiveness and prognosis in a context- and tissue-specific fashion. : The literature was obtained through two main PubMed queries. The first is "miRNA and KLF4 and cancer" and is limited to the last 5 years. The second is "circRNA and KLF4", which yielded publications between 2013 and 2024. The oncological publications were selected. : A number of circRNA/miRNA axes that regulate the downstream transcription factor emerged in the last few years. circRNAs act as sponges for miRNAs and synergize with , which can function as either a tumor promoter or suppressor in different tumors. : The axes represented by circRNA/miRNA/ emerged as a new layer of epigenetic regulation. These RNA-based modulators explain the complex regulation of this transcription factor and open the way to new therapeutic targeting possibilities.
Krüppel样因子4（KLF4）在包括细胞重编程和恶性细胞增殖在内的多种情况下作为一种表观遗传调控基因出现。本手稿的目的是探讨近年来环状RNA、微小RNA（miRNA）与KLF4之间描述的关系。这些已被证明参与了具有不同组织学起源的癌症，包括一些对人类最普遍和致命的肿瘤。这种转录因子的表达和蛋白质水平在特定背景和组织中与侵袭性和预后相关。
文献是通过两个主要的PubMed查询获得的。第一个是“miRNA与KLF4与癌症”，限于过去5年。第二个是“环状RNA与KLF4”，产生了2013年至2024年期间的出版物。选择了肿瘤学出版物。
在过去几年中出现了一些调节下游转录因子KLF4的环状RNA/miRNA轴。环状RNA充当miRNA的海绵，并与KLF4协同作用，KLF4在不同肿瘤中既可以作为肿瘤促进因子也可以作为肿瘤抑制因子发挥作用。
由环状RNA/miRNA/KLF4代表的轴作为表观遗传调控的新层面出现。这些基于RNA的调节因子解释了这种转录因子的复杂调控，并为新的治疗靶向可能性开辟了道路。
