Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Am J Ophthalmol. 2020 Jul;215:37-48. doi: 10.1016/j.ajo.2020.03.009. Epub 2020 Mar 21.
To determine whether eyes with open-angle glaucoma (OAG) and a localized choroidal microvasculature dropout (MvD) are associated with a greater degree of generalized choroidal vascular insufficiency within the β-parapapillary atrophy (β-PPA) than OAG eyes without MvD.
Retrospective cross-sectional study.
This study included 100 OAG eyes with visual field (VF) loss confined to a single hemifield (50 with and 50 without MvD, matched for age [≤10 years ols], axial length [≤1 mm], and VF severity [≤1 dB]), as well as 50 healthy eyes. Using optical coherence tomography angiography, parapapillary choroidal vessel density (pCVD) was measured on en-face images of choroidal maps within the entire β-PPA after excluding the MvD area and hemi-sectors of the β-PPA. pCVDs were compared among the 3 groups. The relationships between pCVD outcomes and various clinical variables were assessed. Logistical regression analyses were performed to determine the clinical factors associated with the presence of MvD in eyes with OAG.
pCVDs corresponding to the VF-intact hemi-sectors and the entire β-PPA, excluding the MvD area, were significantly lower in eyes with MvD than in matched sectors of eyes without MvD. Multivariate linear regression analysis showed that the presence of MvD and greater MvD angular extent were independently associated with lower global pCVD in OAG eyes (all P < .05). Logistic regression analyses showed that lower pCVD was the only factor significantly associated with the presence of MvD.
Localized MvD was a strong predictor of generalized pCVD loss within the β-PPA in OAG eyes.
确定具有开角型青光眼 (OAG) 和局部脉络膜微血管丢失 (MvD) 的眼睛是否比没有 MvD 的 OAG 眼睛在 β 旁视盘萎缩 (β-PPA) 中具有更大程度的广义脉络膜血管不足。
回顾性横断面研究。
本研究纳入了 100 只视野 (VF) 局限于单一半视野的 OAG 眼 (50 只伴 MvD，50 只不伴 MvD，年龄 [≤10 岁]、眼轴 [≤1 毫米] 和 VF 严重程度 [≤1 分贝] 匹配)，以及 50 只健康眼。使用光学相干断层扫描血管造影术，在排除 MvD 区域和 β-PPA 的半扇形后，在整个 β-PPA 的脉络膜地图的面像上测量旁视盘脉络膜血管密度 (pCVD)。比较 3 组之间的 pCVD。评估 pCVD 结果与各种临床变量之间的关系。进行逻辑回归分析以确定与 OAG 眼 MvD 存在相关的临床因素。
在 MvD 眼与无 MvD 眼的匹配扇形中，与 VF 完整扇形和排除 MvD 区域的整个 β-PPA 对应的 pCVD 明显较低。多变量线性回归分析显示，MvD 的存在和更大的 MvD 角范围与 OAG 眼的整体 pCVD 降低独立相关 (均 P <.05)。逻辑回归分析显示，较低的 pCVD 是与 MvD 存在唯一显著相关的因素。
局部 MvD 是 OAG 眼 β-PPA 内广义 pCVD 丧失的一个强有力的预测因子。
