Department of Ophthalmology, HanGil Eye Hospital, Incheon, Korea.
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Sci Rep. 2023 Jan 23;13(1):1281. doi: 10.1038/s41598-023-28288-7.
We sought to investigate the association between optic nerve head (ONH)/choroidal microvasculature perfusion and optic disc hemorrhage (ODH) in eyes with primary open-angle glaucoma (POAG) using swept-source optical coherence tomography angiography (SS-OCTA). A total of 266 POAG eyes (59 with a single instance of ODH, 40 with a history of recurrent ODH, and 167 eyes without ODH) with a mean follow-up of 5.4 years were included. Intradisc vessel density (VD), parapapillary choroidal VD, optic disc microvascular dropout (MvD), and choroidal microvascular dropout (CMvD), were evaluated on a 3 × 3 mm SS-OCTA image of ONH and compared between eyes with and without ODH. Recurrent ODH was defined as occurrence 1 year after first ODH detection during the total follow-up period. Logistic regression analyses were performed to investigate factors associated with ODH. The prevalence of CMvD, optic disc MvD, and β-parapapillary atrophy were not different among the no ODH, single ODH, and recurrent ODH groups. Eyes with ODH had lower intradisc VDs than those without ODH (P = 0.021), but no difference was found in intradisc VDs between the single and recurrent ODH groups (P = 0.977). Better VF MD at baseline (odds ratio [OR], 1.150; 95% confidence interval [CI], 1.055-1.254; P = 0.002) and lower intradisc VD (OR, 0.863; 95% CI, 0.812-0.918; P < 0.001) were associated with ODH occurrence. Among POAG eyes, those with ODH had lower intradisc VDs than those without ODH. POAG eyes in an earlier disease stage or those with lower intradisc VDs should be monitored for the possibility of ODH occurrence.
我们旨在使用扫频源光学相干断层扫描血管造影(SS-OCTA)研究原发性开角型青光眼(POAG)患者视神经头(ONH)/脉络膜微血管灌注与视盘出血(ODH)之间的关系。共纳入 266 只 POAG 眼(59 只单发性 ODH,40 只复发性 ODH,167 只无 ODH),平均随访 5.4 年。在 ONH 的 SS-OCTA 3×3mm 图像上评估视盘内血管密度(VD)、旁视盘脉络膜 VD、视神经盘微血管丢失(MvD)和脉络膜微血管丢失(CMvD),并比较有无 ODH 的眼。复发性 ODH 定义为在总随访期间首次 ODH 检测后 1 年发生。进行逻辑回归分析以研究与 ODH 相关的因素。无 ODH、单发性 ODH 和复发性 ODH 组之间的 CMvD、视盘 MvD 和β-旁视盘萎缩的患病率没有差异。有 ODH 的眼的视盘内 VD 低于无 ODH 的眼(P=0.021),但单发性和复发性 ODH 组之间的视盘内 VD 无差异(P=0.977)。基线时较好的视野 MD(优势比[OR],1.150;95%置信区间[CI],1.055-1.254;P=0.002)和较低的视盘内 VD(OR,0.863;95%CI,0.812-0.918;P<0.001)与 ODH 的发生相关。在 POAG 眼中,有 ODH 的眼的视盘内 VD 低于无 ODH 的眼。处于疾病早期阶段或视盘内 VD 较低的 POAG 眼应监测 ODH 发生的可能性。